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Aldezole (Metronidazole)
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Aldezole

Aldezole is in a class of drugs called nitroimidazole antimicrobials. It works by stopping the growth of bacteria. This medicine will only help infections caused by bacteria and will not work for the common cold, flu, or other viral infections.

Other names for this medication:
Amotein, Fladex, Flagicure, Flanizol, Fortagyl, Gnostol, Gynotran, Metco, Metrobac, Mtronidazole, Nidagel, Nidazole, Nizole, Patryl, Pharmaflex, Protozol, Riazole, Rozacrme, Tismazol, Trichazole, Trichex, Tricodazol, Trogyl, Unigyl, Varizil, Zobacide

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Levaquin, Flagyl, Rulide, Ceftin, Floxin, Cipro, Cefixime, Sumycin, Chloromycetin, Myambutol

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Also known as: Metronidazole

Description

Aldezole (generic name: Metronidazole) is an antibiotic that belongs to a group of medicines called nitroimidazoles.

Aldezole is used for the treatment of susceptible anaerobic bacterial and protozoal infections in the following conditions: amebiasis, symptomatic and asymptomatic trichomoniasis; skin and skin structure infections; CNS infections; intra-abdominal infections (as part of combination regimen); systemic anaerobic infections; treatment of antibiotic-associated pseudomembranous colitis (AAPC); bacterial vaginosis; as part of a multidrug regimen for H. pylori eradication to reduce the risk of duodenal ulcer recurrence.

Dosage

In the Female. One-day treatment – two grams of Aldezole, given either as a single dose or in two divided doses of one gram each, given in the same day. Seven-day course of treatment – 250 mg three times daily for seven consecutive days. There is some indication from controlled comparative studies that cure rates as determined by vaginal smears and signs and symptoms, may be higher after a seven-day course of treatment than after a one-day treatment regimen.

The dosage regimen should be individualized. Single-dose treatment can assure compliance, especially if administered under supervision, in those patients who cannot be relied on to continue the seven-day regimen. A seven-day course of treatment may minimize reinfection by protecting the patient long enough for the sexual contacts to obtain appropriate treatment. Further, some patients may tolerate one treatment regimen better than the other.

Pregnant patients should not be treated during the first trimester In pregnant patients for whom alternative treatment has been inadequate, the one-day course of therapy should not be used, as it results in higher serum levels which can reach the fetal circulation.

When repeat courses of the drug are required, it is recommended that an interval of four to six weeks elapse between courses and that the presence of the trichomonad be reconfirmed by appropriate laboratory measures. Total and differential leukocyte counts should be made before and after re-treatment.

Overdose

In cases of overdose in adults, the clinical symptoms are usually limited to nausea, vomiting, ataxia and slight disorientation. In a preterm newborn, no clinical or biological sign of toxicity developed.

There is no specific treatment for Aldezole overdose, Aldezole infusion should be discontinued. Patients should be treated symptomatically.

Storage

Store at room temperature below 25 degrees C (77 degrees F) away from moisture, light and heat. Keep container tightly closed. Throw away any unused medicine after the expiration date. Keep out of the reach of children.

Side effects

The most common side effects associated with Aldezole are:

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Side effect occurrence does not only depend on medication you are taking, but also on your overall health and other factors.

Contraindications

As a rule, the usual duration of therapy with i.v Metronidazole or other imidazole derivatives is usually less than 10 days. This period may only be exceeded in individual cases after a very strict benefit-risk assessment. Only in the rarest possible case should the treatment be repeated. Limiting the duration of treatment is necessary because damage to human germ cells cannot be excluded.

Intensive or prolonged Metronidazole therapy should be conducted only under conditions of close surveillance for clinical and biological effects and under specialist direction. If prolonged therapy is required, the physician should bear in mind the possibility of peripheral neuropathy or leucopenia. Both effects are usually reversible.

In case of prolonged treatment, occurrence of undesirable effects such as paraesthesia, ataxia, dizziness and convulsive crises should be checked. High dose regimes have been associated with transient epileptiform seizures.

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Total antioxidant activity of low density lipoproteins and the relationship with alpha-tocopherol status. bovis sporozoites and thereby prevent them from infecting host cells. Improvement in WHO functional class was associated with superior survival. The most commonly represented ossicular erosion patterns for primary acquired cholesteatomas demonstrated an intact malleus abutting cholesteatoma, erosion of the incus, and minimal stapes involvement, whereas the common erosion patterns for secondary acquired cholesteatomas demonstrated intact malleus abutting cholesteatoma, erosion of the incus, and erosion of the stapes. The results of this research clearly showed that the efficiency of prosthetic walking for elderly hip disarticulation amputees was very low. Assessing equity in access to health care provision in the UK: does where you live affect your chances of getting a coronary artery bypass graft?. Because stress contributes to obesity and eating behaviors, stress reduction interventions during pregnancy may be a novel way to influence GWG, positively affect maternal and infant outcomes, and address the obesity epidemic intergenerationally.

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DEX substantially reduced maternal food intake and increased water intake in some dams. The patient achieved a complete remission after surgical treatment following radiation and combination chemotherapy. Androgen receptor (AR) inhibitor ErbB3-binding protein-1 (Ebp1) is not targeted by the newly identified AR controlling signaling axis heat-shock protein HSP27 and microRNA miR-1 in prostate cancer cells. Yeast, Saccharomyces cerevisiae, extracts are inactive for translation at 37 degrees C. Acquired gallstone opacification during cholelitholytic treatment with chenodeoxyholic, ursodeoxycholic, and tauroursodeoxycholic acids. Single nucleotide polymorphisms in the IL-8 genes are also associated to increased risk for enteroaggregative Escherichia coli and Clostridium difficile infection. Evidence regarding the effectiveness of psychotherapy for treatment-resistant depression is limited. The discovery of kuru opened new windows into the realms of human medicine and was instrumental in the later transmission of Creutzfeldt-Jakob disease as well as the prediction that bovine spongiform encephalopathy would be transmitted to humans. Analysis of risk factors for pharyngocutaneous fistula after total laryngectomy with particular focus on nutritional status.

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OPL, consisting of two polypeptides with high homology in the N-terminal amino acid sequences, exhibited weak hemagglutinating activity. Controlled release of manganese into water from coated experimental fertilizers: laboratory characterization. Comparative analyses of a total of 29 iga genes showed that pathogenic Neisseria have iga genes with a significantly lower degree of heterogeneity than H. Proximate analyses included fat, ash, calories, total protein, and crude fiber. A case of lumbar hernia occurring through surgical defect of iliac crest. Normal neuronal features of the human gallbladder and structural changes in cholelithiasis patients. We speculate that altered IC connectivity is associated with the experience of chronic pain in individuals with FM.

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The homeobox-containing gene Arx is expressed during ventral telencephalon development and required for correct GABAergic interneuron tangential migration from the ganglionic eminences to the olfactory bulbs, cerebral cortex and striatum. The TMAA transfusion medicine curriculum should provide to medical schools a valuable resource for evaluating their teaching of transfusion medicine and should provide to medical school deans and curriculum committees an authoritative source of transfusion medicine expertise. All patients fulfilled the criteria for the diagnosis of AFND as suggested by Su and Liu. The national waste strategy emphasizes the key role of waste minimization and encourages industry, commerce and the public to move towards sustainable waste management practice for economic and environmental reasons. Optimal treatment for necrotic beetle bites has not been well defined.

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Xanthine oxidase (EC 1.2.3.2) activity increases in liver of rabbits deficient in vitamin E. Exposure of CYP led to a dose-dependent decrease in the male-to-female sex ratio. The following case series evaluated the maxillary sinus augmentation responses to tissue-engineered bone graft obtained by a culture of autogenous osteoblasts seeded on polyglycolic-polylactic scaffolds and calcium phosphate. 4T1 cell, a highly metastatic mouse breast carcinoma cell line, was utilized for in vitro and in vivo assays. PGN mediated an increase in the accumulation of phosphorylated c-Jun in the nucleus, AP-1-luciferase activity, and c-Jun binding to AP-1 element was inhibited by Ly294002, Akt inhibitor, and FAK mutant. In this study we demonstrate that IL-4 producing NBNT cells can induce the switch of lipopolysaccharide-activated B cells to the synthesis of IgG1 and IgE antibodies.

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Lack of association between anemia and renal disease progression in Chinese patients with type 2 diabetes. Erysipelas in quail and suspected erysipeloid in processing plant employees. We present a 64-year-old woman with acute cerebral infarction and multiple cerebral aneurysms complicated by CM. This has prompted the development of a wide variety of techniques for the ex vivo removal or purging of malignant cells from bone marrow and peripheral blood progenitor cell grafts. The word schizoaffective was introduced by Jacob Kasanin in 1933 and has appeared in all editions of the DSM since 1952. The overlapping distribution of receptors for these two peptide hormones in several intrarenal sites may provide an anatomical basis for their physiological interaction to regulate renal hemodynamics and tubular reabsorption of sodium and water.

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Current study aimed to investigate the failure mechanisms of commercial lumbar disc prostheses and to enhance the biomechanical performances of polyethylene components by modifying the articulating surface into a convex geometry. Obesity, in turn, may further alter the gustatory code via forebrain connections to the taste relays or hormonal changes consequent to weight gain. The explanation for the lack of bleeding manifestations is unknown. Different roles of two subgroups of lung vagal C-fiber afferents in the tachypneic response to pulmonary air embolism in dogs. Dicer is a central enzymatic player in RNA-interference pathways that acts to regulate gene expression in nearly all eukaryotes. Chloropyramine hydrochloride reduced tumor growth as a single agent, while concomitant administration with doxorubicin had a pronounced synergistic effect. Consistent with the TEM analysis, nucleolar component proteins, such as upstream binding transcription factor, fibrillarin, nucleolin, and nucleophosmin, showed decreased expression and were structurally disorganized in MB-iSCNT embryos compared to IVF and BB-SCNT embryos, as revealed by real-time PCR and immunofluorescence confocal laser scanning microscopy, respectively. In a prospective study in adult HIV-infected patients, we determined associations between antiretrovirals (ARVs), and in particular the nucleoside reverse transcriptase inhibitor abacavir, and platelet reactivity by measuring time-dependent platelet aggregation in response to agonists: adenosine diphosphate (ADP), thrombin receptor-activating peptide (TRAP), collagen, and epinephrine. Although infectious disease implications have been addressed, little attention has been directed to the potentially negative consequences of care by unfamiliar providers in unfamiliar settings. Treatment of U251 and 5310 glioma cells with U0126, a MEK/ERK inhibitor receded pERK and c-Myc levels.

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To determine whether the overall hemostasis potential (OHP) and calibrated automated thrombogram (CAT) were significantly different between dogs with thrombosis and normal dogs. We report our experience with simultaneous laparoscopic treatment of coexisting kidney and gallbladder pathologies, assess the feasibility of this technique, and highlight some technical considerations. Results show that depression, obesity and alcohol use disorders are interrelated conditions for women. Longitudinal study of nutrient intakes in infants aged 12 to 18 months. The strong antioxidation property of Fucus extract can reduce eye bags and wrinkles while its collagen boosting activity will potentially reduce fine lines and wrinkles. Second, there is the possibility that the aforementioned information may eventually contribute to the development of a drug treatment for the augmentation of skin blood flow and viability in acute skin flaps (i.e., to mimic the surgical delay mechanism).

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A retrospective study was conducted from January 1995 to December 2006 and all consecutive 1242 cases with clinical EPs were included. For nurses, risk of osteonecrosis of the jaw was least important, and for patients and caregivers, mode of administration was least important. Our results demonstrate that the enrichment method, combined with 2D-PAGE and mass spectrometry, can be successfully used to visualize and further identify the sumycin dose low-abundance proteins in the follicular fluid. Long-term outcome of revascularization with composite T-grafts: Is bilateral mammary grafting better than single mammary and radial artery grafting?. Experimental urinary tract infection caused by Escherichia coli in diabetic mouse--uroepithelial colonization and polymorphonuclear leukocyte function. For two weeks, 89 participants provided daily reports of EA, positive and negative affect, enjoyment of daily events and meaning in life (MIL). Histology, ultrastructure and immunopathology of advanced paraproteinemic nephropathy. Procedure guideline for adult solid-meal gastric-emptying study 3.0. Electrocytes of field-caught specimens were significantly larger in all parameters than were electrocytes of specimens maintained in the laboratory. Our results implicate ET-1 as a potential mediator of FFA-induced vascular insulin resistance.

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