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Farnat (Metronidazole)
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Farnat

Farnat belongs to the class of medicines known as antibiotics. It works by killing bacteria or preventing their growth. However, this medicine will not work for colds, flu, or other virus infections.

Other names for this medication:
Aldezole, Amevan, Anegyn, Anerozol, Avidal, Buccoval, Elyzol, Farnat, Fladex, Flagolin, Flagystatin, Flanizol, Flazole, Flegyl, Florazole, Fortagyl, Ginerella, Gynotran, Klion, Metco, Metral, Metrocream, Metrolotion, Metronid, Metronour, Metrosa, Metrozine, Metrozole, Metryl, Nidazea, Noritate, Norzol, Novazole, Padet, Perilox, Protozol, Repligen, Rosasol, Rosazol, Trichozole, Tricodazol, Vagizol

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Also known as: Metronidazole

Description

Farnat (generic name: Metronidazole) is an antibiotic that belongs to a group of medicines called nitroimidazoles.

Farnat is used for the treatment of susceptible anaerobic bacterial and protozoal infections in the following conditions: amebiasis, symptomatic and asymptomatic trichomoniasis; skin and skin structure infections; CNS infections; intra-abdominal infections (as part of combination regimen); systemic anaerobic infections; treatment of antibiotic-associated pseudomembranous colitis (AAPC); bacterial vaginosis; as part of a multidrug regimen for H. pylori eradication to reduce the risk of duodenal ulcer recurrence.

Dosage

The usual adult oral dosage is 7.5 mg/kg every six hours (approx. 500 mg for a 70-kg adult). A maximum of 4 g should not be exceeded during a 24-hour period.

The usual duration of therapy is 7 to 10 days; however, infections of the bone and joint, lower respiratory tract, and endocardium may require longer treatment.

Patients with severe hepatic disease metabolize metronidazole slowly, with resultant accumulation.

Overdose

Single oral doses of Farnat, up to 15 g, have been reported in suicide attempts and accidental overdoses. Symptoms reported include nausea, vomiting, and ataxia. Oral Farnat has been studied as a radiation sensitizer in the treatment of malignant tumors. Neurotoxic effects, including seizures and peripheral neuropathy, have been reported after 5 to 7 days of doses of 6 to 10.4 g every other day.

There is no specific antidote for Farnat overdose; therefore, management of the patient should consist of symptomatic and supportive therapy.

Storage

Store at room temperature below 25 degrees C (77 degrees F) away from moisture, light and heat. Keep container tightly closed. Throw away any unused medicine after the expiration date. Keep out of the reach of children.

Side effects

The most common side effects associated with Farnat are:

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Side effect occurrence does not only depend on medication you are taking, but also on your overall health and other factors.

Contraindications

As a rule, the usual duration of therapy with i.v Metronidazole or other imidazole derivatives is usually less than 10 days. This period may only be exceeded in individual cases after a very strict benefit-risk assessment. Only in the rarest possible case should the treatment be repeated. Limiting the duration of treatment is necessary because damage to human germ cells cannot be excluded.

Intensive or prolonged Metronidazole therapy should be conducted only under conditions of close surveillance for clinical and biological effects and under specialist direction. If prolonged therapy is required, the physician should bear in mind the possibility of peripheral neuropathy or leucopenia. Both effects are usually reversible.

In case of prolonged treatment, occurrence of undesirable effects such as paraesthesia, ataxia, dizziness and convulsive crises should be checked. High dose regimes have been associated with transient epileptiform seizures.

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