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Ladlid (Roxithromycin)
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Ladlid

Ladlid (generic name: roxithromycin; brand names include: Roximycin / Biaxsig / Roxar / Surlid) belongs to a class of drugs known as semi-synthetic macrolide antibiotics. Ladlid is used for the treatment of bacterial infections including infections of the ear, nose and throat, respiratory tract, skin and skin structure infections, and urinary tract infections.

Other names for this medication:
Asmetic, Assoral, Azuril, Biaxsig, Claramid, Delos, Erybros, Macrosil, Makrodex, Overal, Pedilid, Ramivan, Redotrin, Remora, Renicin, Ritosin, Roksimin, Rolexit, Rolicyn, Rolid, Romac, Rotramin, Roxacine, Roxithromycine, Rulid

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Also known as: Roxithromycin

Description

Each Ladlid tablet contains either 150mg or 300mg of the active ingredient roxithromycin. Each tablet also contains: hydroxypropylcellulose, poloxamer, povidone, colloidal anhydrous silica, magnesium stearate (470), purified talc (553), maize starch, hypromellose, anhydrous glucose, titanium dioxide (171), propylene glycol (1520). Ladlid does not contain gluten, sucrose, lactose, tartrazine or any other azo dyes.

Dosage

Ladlid is typically prescribed for a period of 7 to 14 days and patients should take the medication for as long as it has been prescribed to prevent the infection from returning even if they become asymptomatic. Patients should not however, take doses larger than has been prescribed as this can result in an overdose. Overdosing requires immediate medical intervention and may present with symptoms which include abdominal pain, nausea, diarrhea, vomiting, and a general and prolonged feeling of illness.

Overdose

Symptomatic treatment should be provided as required. There is no specific antidote.

Storage

Keep the tablets in the foil until it is time to take them.

Keep the tablets/in a cool dry place where the temperature stays below 30 degrees C.

Do not store Ladlid or any other medicine in the bathroom or near a sink.

Do not leave it in the car on hot days or on window sills.

Heat and dampness can destroy some medicines.

Keep it where children cannot reach it.

A locked cupboard at least one-and-a-half metres above the ground is a good place to store medicines.

Side effects

The most common side effects associated with Ladlid are:

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Side effect occurrence does not only depend on medication you are taking, but also on your overall health and other factors.

Contraindications

The safety of roxithromycin has not been demonstrated in patients with impaired hepatic or renal function. Caution should be exercised if roxithromycin is administered to patients with impaired hepatic or renal function. If administered to patients with severe impaired hepatic function (eg. hepatic cirrhosis with jaundice and/or ascites), consideration should be given to reducing the daily dosage to half the usual dosage.

Prolonged or repeated use of antibiotics including roxithromycin may result in superinfection by resistant organisms. In the event of superinfection, roxithromycin should be discontinued and appropriate therapy instituted.

When indicated, incision, drainage or other appropriate surgical procedures should be performed in conjunction with antibiotic therapy.

Antibiotic associated pseudomembranous colitis has been reported with many antibiotics. A toxin produced by Clostridium difficile appears to be the primary cause. The severity of the colitis may range from mild to life threatening. It is important to consider this diagnosis in patients who develop diarrhoea or colitis in association with antibiotic use (this may occur up to several weeks after cessation of antibiotic therapy). Mild cases usually respond to drug discontinuation alone. However, in moderate to severe cases, appropriate therapy with a suitable oral antibacterial agent effective against Clostridium difficile should be considered. Fluids, electrolytes and protein replacement therapy should be provided when indicated.

Roxithromycin, like erythromycin, has been shown in vitro to elicit a concentration - dependent lengthening in cardiac action potential duration. Such an effect is manifested only at supra – therapeutic concentrations. Accordingly, the recommended doses should not be exceeded. In certain conditions macrolides, including roxithromycin, have the potential to prolong the QT interval. Therefore roxithromycin should be used with caution in patients with congenital prolongation of the QT interval, with ongoing proarrhythmic conditions (ie uncorrected hypokalemia or hypomagnesaemia, clinically significant bradycardia), and in patients receiving Class IA and III antiarrhythmic agents.

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Overweight and obesity in infants and pre-school children in the European Union: a review of existing data. In HEK293FT cells, PRKRIR synergistically enhances type I IFN production mediated by a signal activated- or constitutively active form of RIG-I. No evidence for differential addition of cells to the anterior and posterior divisions was observed. Animal rights activism and animal welfare concerns in the academic setting: levels of activism and the perceived importance of research with animals. Comparison of refractive outcomes using immersion ultrasound biometry and IOLMaster biometry. Mammalian target of rapamycin (mTOR) pathway is activated in viral hepatitis and HCC. As for the Purkinje cells ectopically localized in the cerebellar nuclei and brain stem, the dendritic shafts and cell bodies were strongly labeled. New directions for research in anorexia nervosa are identified and discussed in this report. We found that the proposed algorithm provides more accurate displacement estimates than our previous algorithm for in vivo clinical data. BAC-FISH will be useful for delineating each of the Populus trichocarpa chromosomes and improving the sequence assembly of this model angiosperm tree species.

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