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Loxof (Levofloxacin)

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Loxof belongs to the class of medicines known as quinolone antibiotics. It works by killing bacteria or preventing their growth. However, this medicine will not work for colds, flu, or other virus infections.

Other names for this medication:
Armolev, Auxxil, Cravit, Difloxin, Elequine, Evabit, Ledric, Lefex, Leflox, Lefloxin, Leflumax, Lefoxin, Leoflox, Levobac, Levocine, Levoday, Levof, Levoflox, Levofloxacino, Levofloxacinum, Levomax, Levonidin, Levoproxol, Levores, Levox, Levoxal, Levoxin, Livacin, Locin, Lovicin, Neumoflox, Ovelquin, Potant, Prixar, Proxime, Quinix, Quixin, Recamicina, Reskuin, Rodixina, Septibiotic, Tamiram, Tavanic, Tevox, Ultraquin, Urilev, Voflaxin, Voleflok, Xenoxin, Zidalev

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Also known as: Levofloxacin


To reduce the development of drug-resistant bacteria and maintain the effectiveness of Loxof and other antibacterial drugs, Loxof should be used only to treat or prevent infections that are proven or strongly suspected to be caused by susceptible bacteria. When culture and susceptibility information are available, they should be considered in selecting or modifying antibacterial therapy. In the absence of such data, local epidemiology and susceptibility patterns may contribute to the empiric selection of therapy.

Loxof Tablets/Injection and Oral Solution are indicated for the treatment of adults (≥18 years of age) with mild, moderate, and severe infections caused by susceptible strains of the designated microorganisms in the conditions listed in this section. Loxof Injection is indicated when intravenous administration offers a route of administration advantageous to the patient (e.g., patient cannot tolerate an oral dosage form).


Rapid or bolus intravenous infusion of Loxof has been associated with hypotension and must be avoided. Loxof Injection should be infused intravenously slowly over a period of not less than 60 or 90 minutes, depending on the dosage. Loxof Injection should be administered only by intravenous infusion. It is not for intramuscular, intrathecal, intraperitoneal, or subcutaneous administration.


Overdose of the drug should be strictly avoided and if anyone has accidentally taken the overdose of the drug, then the victim should be provided with emergency medical help. Overdose victim can also consult to their local poison helpline. Some of the overdose symptoms include loss of coordination, drooping eyelids, weakness, decreased activity, trouble breathing, sweating, tremors, or seizure.

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The most common side effects associated with Loxof are:

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Side effect occurrence does not only depend on medication you are taking, but also on your overall health and other factors.


Risk of tendinitis and tendon rupture is increased. This risk is further increased in older patients usually over 60 years of age, in patients taking corticosteroids, and in patients with kidney, heart and lung transplants. Discontinue if pain or inflammation in a tendon occurs.

Anaphylactic reactions and allergic skin reactions, serious, occasionally fatal, may occur after first dose.

Hematologic (including agranulocytosis, thrombocytopenia), and renal toxicities may occur after multiple doses.

Hepatotoxicity: Severe, and sometimes fatal, hepatoxicity has been reported. Discontinue immediately if signs and symptoms of hepatitis occur.

Central nervous system effects, including convulsions, anxiety, confusion, depression, and insomnia may occur after the first dose. Use with caution in patients with known or suspected disorders that may predispose them to seizures or lower the seizure threshold.

Clostridium difficile-associated colitis: evaluate if diarrhea occurs.

Peripheral neuropathy: discontinue if symptoms occur in order to prevent irreversibility.

Prolongation of the QT interval and isolated cases of torsade de pointes have been reported. Avoid use in patients with known prolongation, those with hypokalemia, and with other drugs that prolong the QT interval.

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It was confirmed flotillin-1 (Flot1) as a direct target of miR-485-5p, and up-regulation of miR-485-5p could decrease expression of Flot1 in gastric cancer cells. The results indicate that SHBG may serve as a sensitive biochemical marker of the response to the GH administration. Using the DNP/RNP complexes a discrete DNA polymerase alpha product of approximately 85 kbp was synthesized that was not synthesized in the presence of the DNA polymerase alpha inhibitor aphidicolin. Our study revealed an increase in superiority of the right hand with age on a highly demanding task (Pin Test). We determined the reproductive response of 19-year-old loblolly pine (Pinus taeda) to 4 years of carbon dioxide (CO2) enrichment (ambient concentration plus 200 microliters per liter) in an intact forest. Design and synthesis of lupeol analogues and their glucose uptake stimulatory effect in L6 skeletal muscle cells. Implications for viral uncoating from the structure of bovine enterovirus. The use of adjunctive therapies, directed at risk reduction (eg, aspirin for stroke prophylaxis), require careful scrutiny, but such agents are likely to be vital components of a comprehensive approach to patient care. Is albumin administration beneficial in early stage of postoperative hypoalbuminemia after gastrointestinal surgery: a prospective randomized control trial.

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The Degree of Knee Extension Does Not Affect Postoperative Stability or Subsequent Graft Tear Rate After Anterior Cruciate Ligament Reconstruction With Patellar Tendon Autograft. The anteroposterior dimensions of the TMJ were most strongly consistent with hypothesized differences in ingestive/masticatory behaviors and jaw gape, whereas the predictions generated for variation in entoglenoid and articular tubercle height were not upheld. Regulation of the cell-cell adhesion protein, E-cadherin, in dog and human thyrocytes in vitro. Although non-parasitic cysts of the liver have often been described in adults, solitary non-parasitic cysts are rare in infants. Escherichia coli K-12 OST3410 was isolated previously as a stable cyclohexane-tolerant mutant derived from cyclohexane-sensitive strain JA300. Cortical T2 prolongation is a known feature in later disease stages, but has not been demonstrated in the cortical normal appearing gray matter (NAGM) in early MS. The article concludes with a summary and directions for future research. These findings suggest that the muscle glycogen synthase gene or neighboring genes are related to one of the disease genes of diabetes mellitus without high total cholesterolemia. While other socioeconomic variables could contribute to this phenomenon, further research into the immunologic correlates of the acutely stressful condition of marital separation should be conducted. Vibrant patent review systems require sharing information among developing countries and active consultation with local public health authorities.

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After the results of the Cardiac Arrhythmia Suppression Trial (CAST) were released, this practice was largely abandoned. In humans, mutations resulting in C-terminal truncation cause neutral lipid storage disease with myopathy. Replacement of the glutamine at position 267 with glutamic acid leads to a decreased binding affinity to MHC II. This is accomplished by comparing the mass of protein immobilized to gold surfaces that have been treated in several different fashions, as well as, deposition of the gold on nylon membranes that have been treated differently. Neuron-specific enolase mRNA was highly expressed in most of the large congenital nevi (greater than 15 cm in diameter), as revealed by autoradiography following in situ hybridization. Despite limited evidence of their effectiveness sumycin 250 mg , counsellors are increasingly being employed as part of the primary health care team. Conformation-related exciton localization and charge-pair formation in polythiophenes: ensemble and single-molecule study. Whole mount in situ hybridization confirmed that Cyp11a1 expression was reduced in the null testis, but its distribution pattern was unchanged.

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Fast-track video-assisted bullectomy and pleurectomy for pneumothorax: initial experience and description of technique. A cross-sectional survey of performance of chemotherapy for echinococcosis in Xinjiang Uygur autonomous region. Cerebrospinal fluid (CSF) infection was defined as positive CSF microbiologic culture. These findings provide evidence that GnRH treatment leads to activation of the MAPK cascade in gonadotropes and that activation of MAPK contributes to stimulation of the alpha-subunit promoter. The zithromax tablets 500mg design, synthesis, and activity of a ribozyme that specially cleaves rat 28S rRNA. Among respondents who had ever been drinkers, women in all age groups were consistently more likely to have stopped drinking than men were. In clinical practice, with a clear lens, the TLV could be exceeded easily if the patient is subjected to prolonged or repeated examination because the blue-light hazard is additive in a linear manner for periods as long as 3 hours with a potential for a cumulative effect over longer periods. Host-pathogen interactions of measles virus (MV), a leading cause of childhood mortality worldwide, are still poorly understood.

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Five year clinical evaluation of treatment efficacy with methotrexate in patients with rheumatoid arthritis. The collagenase (pro-MMP-1 and MMP-13, total MMP-1, and MMP-13), gelatinase (total MMP-2 and MMP-9), stromelysin (total MMP-3), matrilysin (total MMP-7), uPA, and tissue inhibitor of MMP (TIMP) levels were measured by ELISA. This study investigated the interaction between COX-2, NO and ROS after ischemia/reperfusion events in the kidney and vascular beds. Stimuli were presented simultaneously in two modalities and were either congruent or incongruent (e.g., left visual object, right sound) with each other. When cultures were incubated with HRP for only 15 min most of the Golgi clusters in the mitotic cells were either unlabeled or consisted of a mixture of HRP-labeled and unlabeled profiles. Glycerol-limited steady states were established for dilution rates between 0.004 and 0.018 h(-1). To measure the distraction force and its relaxation during a period of up to 3 hours after disc-space distraction as a function of the distraction magnitude and disc level. The decrease in the proliferative capacity of mast cells caused by phorbol ester and dexamethasone was simultaneous to an increase in histamine production. We investigated whether factor V Leiden is a risk factor for LV thrombus in patients with acute myocardial infarction (AMI).

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