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Loxof (Levofloxacin)
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Loxof

Loxof belongs to the class of medicines known as quinolone antibiotics. It works by killing bacteria or preventing their growth. However, this medicine will not work for colds, flu, or other virus infections.

Other names for this medication:
Armolev, Auxxil, Cravit, Difloxin, Elequine, Evabit, Ledric, Lefex, Leflox, Lefloxin, Leflumax, Lefoxin, Leoflox, Levobac, Levocine, Levoday, Levof, Levoflox, Levofloxacino, Levofloxacinum, Levomax, Levonidin, Levoproxol, Levores, Levox, Levoxal, Levoxin, Livacin, Locin, Lovicin, Neumoflox, Ovelquin, Potant, Prixar, Proxime, Quinix, Quixin, Recamicina, Reskuin, Rodixina, Septibiotic, Tamiram, Tavanic, Tevox, Ultraquin, Urilev, Voflaxin, Voleflok, Xenoxin, Zidalev

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Vantin, Ilosone, Avelox, Cleocin, Omnicef, Biaxin, Rulide

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Also known as: Levofloxacin

Description

To reduce the development of drug-resistant bacteria and maintain the effectiveness of Loxof and other antibacterial drugs, Loxof should be used only to treat or prevent infections that are proven or strongly suspected to be caused by susceptible bacteria. When culture and susceptibility information are available, they should be considered in selecting or modifying antibacterial therapy. In the absence of such data, local epidemiology and susceptibility patterns may contribute to the empiric selection of therapy.

Loxof Tablets/Injection and Oral Solution are indicated for the treatment of adults (≥18 years of age) with mild, moderate, and severe infections caused by susceptible strains of the designated microorganisms in the conditions listed in this section. Loxof Injection is indicated when intravenous administration offers a route of administration advantageous to the patient (e.g., patient cannot tolerate an oral dosage form).

Dosage

Rapid or bolus intravenous infusion of Loxof has been associated with hypotension and must be avoided. Loxof Injection should be infused intravenously slowly over a period of not less than 60 or 90 minutes, depending on the dosage. Loxof Injection should be administered only by intravenous infusion. It is not for intramuscular, intrathecal, intraperitoneal, or subcutaneous administration.

Overdose

Overdose of the drug should be strictly avoided and if anyone has accidentally taken the overdose of the drug, then the victim should be provided with emergency medical help. Overdose victim can also consult to their local poison helpline. Some of the overdose symptoms include loss of coordination, drooping eyelids, weakness, decreased activity, trouble breathing, sweating, tremors, or seizure.

Storage
Side effects

The most common side effects associated with Loxof are:

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Side effect occurrence does not only depend on medication you are taking, but also on your overall health and other factors.

Contraindications

Risk of tendinitis and tendon rupture is increased. This risk is further increased in older patients usually over 60 years of age, in patients taking corticosteroids, and in patients with kidney, heart and lung transplants. Discontinue if pain or inflammation in a tendon occurs.

Anaphylactic reactions and allergic skin reactions, serious, occasionally fatal, may occur after first dose.

Hematologic (including agranulocytosis, thrombocytopenia), and renal toxicities may occur after multiple doses.

Hepatotoxicity: Severe, and sometimes fatal, hepatoxicity has been reported. Discontinue immediately if signs and symptoms of hepatitis occur.

Central nervous system effects, including convulsions, anxiety, confusion, depression, and insomnia may occur after the first dose. Use with caution in patients with known or suspected disorders that may predispose them to seizures or lower the seizure threshold.

Clostridium difficile-associated colitis: evaluate if diarrhea occurs.

Peripheral neuropathy: discontinue if symptoms occur in order to prevent irreversibility.

Prolongation of the QT interval and isolated cases of torsade de pointes have been reported. Avoid use in patients with known prolongation, those with hypokalemia, and with other drugs that prolong the QT interval.

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It was confirmed flotillin-1 (Flot1) as a direct target of miR-485-5p, and up-regulation of miR-485-5p could decrease expression of Flot1 in gastric cancer cells. The results indicate that SHBG may serve as a sensitive biochemical marker of the response to the GH administration. Using the DNP/RNP complexes a discrete DNA polymerase alpha product of approximately 85 kbp was synthesized that was not synthesized in the presence of the DNA polymerase alpha inhibitor aphidicolin. Our study revealed an increase in superiority of the right hand with age on a highly demanding task (Pin Test). We determined the reproductive response of 19-year-old loblolly pine (Pinus taeda) to 4 years of carbon dioxide (CO2) enrichment (ambient concentration plus 200 microliters per liter) in an intact forest. Design and synthesis of lupeol analogues and their glucose uptake stimulatory effect in L6 skeletal muscle cells. Implications for viral uncoating from the structure of bovine enterovirus. The use of adjunctive therapies, directed at risk reduction (eg, aspirin for stroke prophylaxis), require careful scrutiny, but such agents are likely to be vital components of a comprehensive approach to patient care. Is albumin administration beneficial in early stage of postoperative hypoalbuminemia after gastrointestinal surgery: a prospective randomized control trial.

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This method also helps to investigate the interactions between histone modification and DNA methylation, and how this crosstalking can affect gene expression. The purified protein encoded by the CL100 open reading frame expressed in bacteria has intrinsic phosphatase activity. We can expect that future design modifications will continue improve the performance with the adjustable gastric band. Through our review of the literature, we identified areas of concordance and disagreement. This report contains a statistical study of 874 cases of epulis diagnosed by the Department of Pathology of Tokyo Dental College from 1966 to 1986.

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Five year clinical evaluation of treatment efficacy with methotrexate in patients with rheumatoid arthritis. The collagenase (pro-MMP-1 and MMP-13, total MMP-1, and MMP-13), gelatinase (total MMP-2 and MMP-9), stromelysin (total MMP-3), matrilysin (total MMP-7), uPA, and tissue inhibitor of MMP (TIMP) levels were measured by ELISA. This study investigated the interaction between COX-2, NO and ROS after ischemia/reperfusion events in the kidney and vascular beds. Stimuli were presented simultaneously in two modalities and were either congruent or incongruent (e.g., left visual object, right sound) with each other. When cultures were incubated with HRP for only 15 min most of the Golgi clusters in the mitotic cells were either unlabeled or consisted of a mixture of HRP-labeled and unlabeled profiles. Glycerol-limited steady states were established for dilution rates between 0.004 and 0.018 h(-1). To measure the distraction force and its relaxation during a period of up to 3 hours after disc-space distraction as a function of the distraction magnitude and disc level. The decrease in the proliferative capacity of mast cells caused by phorbol ester and dexamethasone was simultaneous to an increase in histamine production. We investigated whether factor V Leiden is a risk factor for LV thrombus in patients with acute myocardial infarction (AMI).

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