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Metrol (Metronidazole)
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Metrol

Metrol is a medicine used to treat different types of bacterial and parasitic infections, including those that affect the skin, vagina, blood, heart, bone, stomach, liver, joints, nervous system, respiratory tract, and other areas of the body.

Other names for this medication:
Aldezole, Amodis, Birodogyl, Dirozyl, Dumozol, Flagystatine, Fortagyl, Gnostol, Lindoplus, Litagyl, Medazol, Metral, Metrin, Metronex, Metronidazol, Metronidazolum, Metronide, Metrosil, Metrovax, Molazol, Nidazea, Nidazole, Rhodogil, Rosaced, Rozagel, Trichomonacid, Trikozol, Zyomet

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Also known as: Metronidazole

Description

Metrol (generic name: Metronidazole) is an antibiotic that belongs to a group of medicines called nitroimidazoles.

Metrol is used for the treatment of susceptible anaerobic bacterial and protozoal infections in the following conditions: amebiasis, symptomatic and asymptomatic trichomoniasis; skin and skin structure infections; CNS infections; intra-abdominal infections (as part of combination regimen); systemic anaerobic infections; treatment of antibiotic-associated pseudomembranous colitis (AAPC); bacterial vaginosis; as part of a multidrug regimen for H. pylori eradication to reduce the risk of duodenal ulcer recurrence.

Dosage

In elderly patients, the pharmacokinetics of metro- nidazole may be altered, and, therefore, monitor- ing of serum levels may be necessary to adjust the metronidazole dosage accordingly.

Overdose

Single oral doses of Metrol, up to 15 g, have been reported in suicide attempts and accidental overdoses. Symptoms reported include nausea, vomiting, and ataxia. Oral Metrol has been studied as a radiation sensitizer in the treatment of malignant tumors. Neurotoxic effects, including seizures and peripheral neuropathy, have been reported after 5 to 7 days of doses of 6 to 10.4 g every other day.

There is no specific antidote for Metrol overdose; therefore, management of the patient should consist of symptomatic and supportive therapy.

Storage

Store below 77 degrees F (25 degrees C) and protect from light.

Side effects

The most common side effects associated with Metrol are:

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Side effect occurrence does not only depend on medication you are taking, but also on your overall health and other factors.

Contraindications

As a rule, the usual duration of therapy with i.v Metronidazole or other imidazole derivatives is usually less than 10 days. This period may only be exceeded in individual cases after a very strict benefit-risk assessment. Only in the rarest possible case should the treatment be repeated. Limiting the duration of treatment is necessary because damage to human germ cells cannot be excluded.

Intensive or prolonged Metronidazole therapy should be conducted only under conditions of close surveillance for clinical and biological effects and under specialist direction. If prolonged therapy is required, the physician should bear in mind the possibility of peripheral neuropathy or leucopenia. Both effects are usually reversible.

In case of prolonged treatment, occurrence of undesirable effects such as paraesthesia, ataxia, dizziness and convulsive crises should be checked. High dose regimes have been associated with transient epileptiform seizures.

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The study of the absorption kinetics of guanyl-cysteine from small intestine of rats was performed with the experimental technique proposed by Doluisio. Do changes in antimicrobial resistance necessitate reconsideration of surgical antimicrobial prophylaxis strategies?. Spontaneous (nontraumatic) rupture of spleen is an uncommon situation and it happens very rarely due to neoplastic metastasis. Phospholipase C isozymes are deregulated in colorectal cancer--insights gained from gene set enrichment analysis of the transcriptome. This review summarizes the therapeutic options in NSCLC, as well as the background and rationale for targeting TS. Clinical findings were pain due to bilateral inflammation of the lumbar nerve roots, fistulised cold abcess and motor deficit in both lower extremities. The commonest cranial CT findings reported in toxoplasmosis are ring enhancing hypodense lesions in basal ganglia or cortical gray matter. The Electronic Medical Records and Genomics (eMERGE) network, initiated in 2007, is an NIH-funded consortium devoted to genomic discovery and implementation research by leveraging biorepositories linked to EMRs. Adrenal tumors discovered incidentally on ultrasonography: three case reports.

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