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Quantrum (Levofloxacin)
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Quantrum

Quantrum is used to treat infections of the sinuses, skin, lungs, ears, airways, bones, and joints caused by susceptible bacteria. Levofloxacin is frequently used to treat urinary infections, including those resistant to other antibiotics, as well as prostatitis (infection of the prostate).

Other names for this medication:
Bacnil, Corvox, Cravit, Difloxin, Elequine, Floracid, Isofloxx, Ledric, Lefex, Leflox, Levocine, Levoday, Levoking, Levomax, Levonidin, Levonix, Levoquin, Levoquinol, Levores, Levosina, Levotac, Levox, Levoxacin, Locin, Mosardal, Nislev, Oftaquix, Ovelquin, Prolecin, Recamicina, Rinvox, Rodixina, Teraquin, Tevox, Trevox, Uniflox, Urilev, Volequin, Volox, Yaxinbituo

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Also known as: Levofloxacin

Description

To reduce the development of drug-resistant bacteria and maintain the effectiveness of Quantrum and other antibacterial drugs, Quantrum should be used only to treat or prevent infections that are proven or strongly suspected to be caused by susceptible bacteria. When culture and susceptibility information are available, they should be considered in selecting or modifying antibacterial therapy. In the absence of such data, local epidemiology and susceptibility patterns may contribute to the empiric selection of therapy.

Quantrum Tablets/Injection and Oral Solution are indicated for the treatment of adults (≥18 years of age) with mild, moderate, and severe infections caused by susceptible strains of the designated microorganisms in the conditions listed in this section. Quantrum Injection is indicated when intravenous administration offers a route of administration advantageous to the patient (e.g., patient cannot tolerate an oral dosage form).

Dosage

The usual dose of Quantrum Tablets or Oral Solution is 250 mg, 500 mg, or 750 mg administered orally every 24 hours, as indicated by infection and described in Table 1. The usual dose of Quantrum Injection is 250 mg or 500 mg administered by slow infusion over 60 minutes every 24 hours or 750 mg administered by slow infusion over 90 minutes every 24 hours.

Overdose

Overdose of the drug should be strictly avoided and if anyone has accidentally taken the overdose of the drug, then the victim should be provided with emergency medical help. Overdose victim can also consult to their local poison helpline. Some of the overdose symptoms include loss of coordination, drooping eyelids, weakness, decreased activity, trouble breathing, sweating, tremors, or seizure.

Storage
Side effects

The most common side effects associated with Quantrum are:

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Side effect occurrence does not only depend on medication you are taking, but also on your overall health and other factors.

Contraindications

Risk of tendinitis and tendon rupture is increased. This risk is further increased in older patients usually over 60 years of age, in patients taking corticosteroids, and in patients with kidney, heart and lung transplants. Discontinue if pain or inflammation in a tendon occurs.

Anaphylactic reactions and allergic skin reactions, serious, occasionally fatal, may occur after first dose.

Hematologic (including agranulocytosis, thrombocytopenia), and renal toxicities may occur after multiple doses.

Hepatotoxicity: Severe, and sometimes fatal, hepatoxicity has been reported. Discontinue immediately if signs and symptoms of hepatitis occur.

Central nervous system effects, including convulsions, anxiety, confusion, depression, and insomnia may occur after the first dose. Use with caution in patients with known or suspected disorders that may predispose them to seizures or lower the seizure threshold.

Clostridium difficile-associated colitis: evaluate if diarrhea occurs.

Peripheral neuropathy: discontinue if symptoms occur in order to prevent irreversibility.

Prolongation of the QT interval and isolated cases of torsade de pointes have been reported. Avoid use in patients with known prolongation, those with hypokalemia, and with other drugs that prolong the QT interval.

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These data suggest that aqueous samples are useful for investigating potential involvement of molecular targets in various disease processes and for pharmacokinetic or pharmacodynamic studies. The deduced protein had a calculated molecular weight of 31.3 kilodaltons. Clinical evaluation of SD-8828 (antibody coated bacteria assay kit) in urinary tract infection. In the present study, we aimed to evaluate the association between dietary protein intakes and the risk of developing incident UC. The risk of AKI may also increase as a result of aggressive diagnostic and therapeutic procedures, which include medical agents, radiology, and surgical intervention. To be transparent to the learners, marketing materials identify the parties involved and prominently note the name of the organization accountable for developing the activity and awarding the contact hours. Derived Michaelis-Menton constants were used to convert the doses of combined metabolites from the pharmacokinetic studies to the doses used in the bioassays. We characterize the time-evolving relationships between the different assets by investigating the correlations between the asset price time series and principal components.

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This article reviews the preventive measures that should be taken in LTCFs to reduce the risk of device-related infections. Hydrogen bonds are essential for the structure, stability and folding of proteins. Coronary and left-heart angiography in assessment of chest pain. The AccuBoost treatment can be performed with the (60)Co source and thick-wall applicators instead of (192)Ir with standard applicators. Prompt initiation of treatment with an oral antifungal agent, such as itraconazole, should be undertaken in order to avoid irreversible scarring alopecia. Promoter polymorphism at the tumour necrosis factor/lymphotoxin-alpha locus is associated with type of diabetes but not with susceptibility to sight-threatening diabetic retinopathy. A striatal phantom filled with (123)I using striatal to background ratios between 2:1 and 10:1 was imaged on five different gamma camera systems.

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To explore the significance of this activity, we investigated the ability of RDH11 and RDH12 to protect stably transfected HEK-293 cells against the toxicity of 4-HNE. The fabrication of metallic tips with a silicon cantilever for probe-based ferroelectric data storage and their durability experiments. Routine removal of nonspinal, orthopedic implants from pediatric patients is a debated practice. Water relations during desiccation of cysts of the potato-cyst nematode Globodera rostochiensis. We hypothesized that the anti-angiogenic drug sunitinib abrogates alterations in microvascular properties following a minor surgical intervention in an in vivo model of secondary breast cancer growth in the bone. The chronic recurrent migraine resolved over a 12-week period with use of chiropractic rehabilitation in this patient. Angiogenesis has a clear and definite role in the breast cancer progression process, making antivascular endothelial growth factor (VEGF) therapies an attractive option for the treatment of metastatic breast cancer (MBC).

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Ethanol production from sunflower meal biomass by simultaneous saccharification and fermentation (SSF) with Kluyveromyces marxianus ATCC 36907. WASP may be involved in the regulation of podosome, an actin-rich dynamic cell adhesion structure formed by various types of cells. The survey of 8 years after recovery suggests that this technique is a viable alternative when patients do not opt for surgery. Histopathology of the transbronchial lung biopsy specimens showed immature noncaseating granulomata. Protective effect of an organic germanium compound on warm ischemia and prolonged kidney preservation. (2) This poor perfusion is inadequate to meet myocardial demands as demonstrated by the high right ventricular oxygen extraction after a prolonged retrograde infusion. We tested these two biologic moieties separately and in combination for their activity on MSCs. Drawing from natural cues, these scaffolds may represent a new avenue forward for advanced bone tissue engineering scaffolds. However, the unusual oceanography in the coasts of China and Korea suggests potential for restricted dispersal of pelagic larvae and geographical differentiation. With the use of a conformation-specific antibody and tryptic digestion assays, we showed that glycosylation at the Asn-89 site of vIL-6 affected protein conformation.

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Objectively assessed operative risk was not prohibitive in many unoperated patients. Antibacterial soap alone or combined with microwave heating was advocated to decrease pathogens and bacterial residue, which could inoculate the bladder from a colonized catheter. Thus, the MEPE/PHEX ratio may be a good indicator of mineralization progression because we found that the mRNA ratio and protein levels were low when osteoblasts were actively differentiating to the mineralization stage and the ratio was high when the cells reached the mineralization stage when it is assumed that osteocytes may protect themselves and make a space to survive from the mineralized matrix by releasing the ASARM motif. Axonal aggregates of phosphorylated (p-) transactive response DNA-binding protein 43 kDa (TDP-43) in sporadic amyotrophic lateral sclerosis (sALS) were examined in relation to propagation of the protein in the nervous system. Maize non-photosynthetic ferredoxin precursor is mis-sorted to the intermembrane space of chloroplasts in the presence of light. Renal transplant tourism has become widely established in the UK and the Republic of Ireland, and care for these patients is often suboptimal. Evaluation of fibrosis in the disse space in noncirrhotic alcoholic liver disease. Pharmacologic inhibition of Rho kinases in neurons diminished detergent-soluble and -insoluble tau through a combination of autophagy enhancement and tau mRNA reduction. There were no significant correlations between impedance, charge, energy, or rate of increase in charge on the one hand, and clinical improvement on the other. Hospital safety-net burden was defined as the percent of cancer patients per facility that were Medicaid-insured or uninsured.

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Observations on the dentition and face in clefts of the alveolar process. actinomycetemcomitans strains were characterized by polymerase chain reaction. In contrast, higher levels of phosphatidylcholine PC ae C30:0 were associated with increased cancer risk. Conformational problems tend to be common in llamas and alpacas. CF-like disease has been reported in a heterozygous carrier of F508del CFTR and the hyperactive variant p.W493R-SCNN1A of the epithelial sodium channel (ENaC). Matrix metalloproteinase-2 is elevated in midtrimester amniotic fluid prior to the development of preeclampsia. The outcome was considered successful if the TM was intact without lateralization or anterior blunting after the follow-up visit.

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Conivaptan is a nonpeptide vasopressin V(1A)/V(2)-receptor antagonist that produces a controlled increase in serum sodium concentration in hospitalized patients with euvolemic or hyper-volemic hyponatremia. In this report, we will review the recent history of YAC/BAC/PAC-transgenic animals indicating their benefits and the potential problems associated with them. Health co-benefits in mortality avoidance from implementation of the mass rapid transit (MRT) system in Kuala Lumpur, Malaysia. Familial examination revealed that this mutation had occurred de-novo in the proband. The growth of dendritic spines is modulated by NRG1/ErbB4 through NMDARs as these activate small Rho-GTPases, such as kalirin, which control the actin cytoskeleton in the spines responsible for their growth. Twelve weeks after infection, chronic granulomatous inflammation led to proliferation of the muscle layer and to a further increase in MPO activity, whereas IL-1beta production normalized. Hepaticocholecystoduodenostomy compared with Roux-en-y choledochojejunostomy for decompression of the biliary tract. Adjunctive use of laser Doppler flowmetry for debridement of osteomyelitis. The kinetics and extent of the reaction was dependent on protein concentration, pH, and temperature. The distribution of metastatic foci in the 100 node-positive patients who had undergone curative gastrectomy were classified into two groups: (1) massive type, in which the tumor occupied the entire lymph node, and (2) non-massive type, in which the tumor did not occupy the entire lymph node.

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There is no conclusive evidence of a difference in satisfaction rates between surgery and LNG-IUS, though adverse effects such as bleeding and spotting are more likely to occur with LNG-IUS. Lymphocytes and macrophages in adult chronic periodontal disease. The ray set makes it possible to develop and simplify bracket placement methods without a preliminary set-up, while taking an accurate reading of the marginal ridge to establish the height of slots. The width (FWHM) of the observed resonances corresponds to 60 kHz. The association with other biological factors and the prognostic impact of BM positivity and clinical response was assessed. Membrane-bound D-lactate dehydrogenase of Escherichia coli: a model for protein interactions in membranes. The ventilatory responses to exercise were studied in a group of such patients to assess relations between ventilation, exercise capacity, and right ventricular function. Vaccines, mechanism of action, duration of the inoculation protection and revaccination.

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Discrimination of taste qualities among mouse fungiform taste bud cells. Many of the proteins found in the culture filtrate had predicted functions relating to modification of the plant cell wall, a major activity required for pathogenesis on the plant host, including a number found only under infection conditions. In order to characterize the global gene activity correlated with each particular stage of neural development, the full transcriptome of different cell populations that arise during the in vitro differentiation protocol was determined by microarray analysis. Previous research indicated that graphene oxide (GO) can be used to deliver photosensitive anticancer drug, Hypocrellin A (HA), in photodynamic therapy (PDT). S1P-triggered cell migration was directly related to S1P1 expression. Prognostic factors and treatment outcomes of 100 cases of anaplastic thyroid carcinoma. Identification of differentially expressed genes in scrapie-infected mouse neuroblastoma cells.

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To explore how nurses in North Carolina are managing communication issues, 55 nurses at 12 state health care agencies that serve migrant farmworkers was surveyed. Using the three-dimensional finite difference time-domain (3-D FDTD) method with perfect matched layer (PML) absorbing boundary condition (ABC), the diffraction efficiency is calculated for each designed FADOE and the corresponding values are compared. Effect of octreotide on fasting gall bladder emptying, antroduodenal motility, and motilin release in acromegaly. The stainless steel instruments used lead to greater modifications being required in the canals than those made of nickel-titanium. There were no diferences in caffeine and high-fat food intake between mild and severe mastalgia. Using the antibodies, we show that phosphorylation of TMAP at Thr-578 and Thr-596 indeed occurs specifically during mitosis.

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Continuing education in state hospitals using external consultants. The aetiology of the cystic endometrial hyperplasia/pyometra complex and its possible role in the development of inflammatory polypoid lesions in the bitch is also discussed. After acute myocardial infarction, approximately one third of patients have ST segment depression on Holter monitoring, independent of the use of thrombolytic therapy. Radiographic imaging requirements following ventriculoperitoneal shunt procedures. Transplantation tolerance in heart transplant recipients as demonstrated by unresponsiveness in cell-mediated lympholysis. In animals subjected to an increase in LAP and subsequently to infusion of E. The association of bacterial virulence with the host response to bacteriuria was evaluated in 70 pregnant women with acute pyelonephritis or bacteriuria detected at screening.

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Transcripts of the interviews were analyzed using a combination of grounded theory and content analysis to describe their experience of this screening practice. From 2003 to 2011, the mortality rate from OLD decreased substantially in the Yangpu district of Shanghai. Surveillance of Physicians Causing Potential Drug-Drug Interactions in Ambulatory Care: A Pilot Study in Switzerland. Polymeric capsule-cushioned leukocyte cell membrane vesicles as a biomimetic delivery platform. A 31P-nuclear magnetic resonance study of intermittent warm blood cardioplegia. Sex, age, NET site, chromogranin A levels, neuropeptide secretion and disease stage were compared between NETs with and without SPMs. Metabolic disorders presented a high prevalence in Japanese-Brazilians with significant correlations with necrosis and hypertrophy on the ECG.

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The diagnosis of middle vault insufficiency and techniques to prevent and repair such collapse have been widely reported. Liver ischemia/reperfusion (I/R) injury is a high risk factor in liver transplantation and it influences graft survival. A 26-year-old male patient gradually developed muscular atrophy of the right lower leg over a two-year period. Eighteen retrospective studies including a total of 9270 patients were identified. Negative experiences of maternal care and eating disorder pathology also contributed a small but significant amount to the variance in shame scores. Topical fibronectin in the treatment of keratoconjunctivitis sicca.

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Forced expiratory volume in 1 second, nasal peak flow, the fraction of exhaled nitric oxide (FeNO), and eicosanoid levels in plasma and urine were analyzed. Moreover, androgens were converted into a glucuronide conjugate in LNCaP, but not in PC-3 or DU145. This prophylactic effect of rhSOD amy be due, in noroxin 400 mg precio part, to decreased chemical mediators such as activated complements, cytokines, and arachidonic acid metabolites. We now show with immunoelectron microscopy that actin becomes associated with the BR particle concomitantly with transcription and is present in the particle in the nucleoplasm. The risk of developing cerebral palsy is nearly doubled and the risk of developing epilepsy is also higher. Skin lesions, bone involvements and the hereditary character of the disease are described. Update on the role of the complement system in the pathogenesis of thrombotic microangiopathies. Base excess levels after extubation were significantly decreased compared with baseline. Genetic mouse models for bone studies--strengths and limitations. It can identify features known to be associated with increased risk of metastatic disease.

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Therefore, a DA-mediated increase in cerebral blood flow in the cerebral cortex cannot be expected. The aim of this study was to assess the will flagyl treat a urinary tract infection impact of heart transplantation on the feasibility and complications of the dobutamine stress test. Our results show that for some parameters the forced FitzHugh-Nagumo neuron model has two attractors: the small-amplitude subthreshold periodic oscillation and the large-amplitude suprathreshold periodic oscillation. We found that MG132 inhibited the proliferation of human NSCLC cell lines (A549 and H1299) in a dose- and time-dependent manner by 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide assay. The antagonist effect of SKF-86466 at alpha(2)-ARs was evident both as a reversal of the ventilatory disturbances produced by the alpha2-AR agonist clonidine (5 microg/kg IV) and as a rightward shift in the potency of the agonist-evoked response after SKF-86466 pretreatment. Developmental bias for number words in the intraparietal sulcus. Recently, host-targeted therapies (HDT) have gained attention as a means to shorten the course of treatment of drug-sensitive TB, improve treatment outcomes of drug-resistant TB and generally improve the efficacy and preserve or restore lung architecture of TB patients. The unfrozen water fraction per molecule was determined from differential scanning calorimetry measurements of their aqueous solutions.

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Multicenter data reported to Extracorporeal Life Support Organization registry. Chicken embryos were exposed to formaldehyde vapors in the hatcher during the final 3 days of incubation. Extended time interval from the onset of initial symptoms to appendectomy is associated with increased complications per CCI, duration of surgery, and HLOS in acute appendicitis. However, most published data are for North American, British and Jewish populations. Despite syrinx decrease on follow-up MR scan, further clinical deterioration led to re-exploration of the cranio-cervical junction. SOC and the SDQ-em showed the best ability to differentiate cases of anxiety disorders and/ or depression from non-cases.

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The other two cases were misdiagnosed as ASD or VSD by right heart catheterization and ventriculography. We examined the most recent literature in order to concisely review the evidence for some amoxil dosing pediatrics of the most important recent advances in the putative mechanisms concerned in the pathophysiology of VPH. Doppler ultrasound may provide useful information on coexisting intracardiac abnormalities, but in the presence of ductal patency is of little value in the diagnosis of coarctation itself. We prospectively analyzed the correlation of 28 different PEFvar indexes (including 4 NHLBI-compatible indexes) with MIC and pre-BD and post-BD FEV(1) responses in suspected asthmatic subjects with normal findings on lung examination, chest radiography, and baseline spirometry. Although the aggressive treatment of reversible risk factors, such as lipids and blood pressure, is advocated by many, no published studies have yet demonstrated a clear reduction in risk of coronary events with this approach. The Leishmania LPG3 antigen can effectively activate NK cells, in vitro. The impact the order will have on the authorization of animal experiments and testing in Germany caused an outrage in the animal welfare community. 381 patients with disc haemorrhages and 164 with thrombosis (T) were found and followed when possible.

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A central scar in hepatic focal nodular hyperplasia detected on liver SPECT imaging. Accidental podophyllin poisoning is rare, but it can be associated with high morbidity and mortality. The Arrhenius plot of the association rate constant shows that the activation energy was 38.8 kcal/mol, but the hybridization process may involve several components. Modeling the contribution of synchronous chemotherapy to the rate of grade 3 and 4 mucositis in locally advanced squamous cell carcinoma of the head and neck. In our current study, we provide evidence that clonal individuals display phenotypic variability within asexual morph categories. All had improved with nilutamide, with a dramatic decrease of prostate specific antigen levels. Alleles were assigned according to the International Society for Forensic Haemogenetics (ISFH) recommendations. Surface properties of membrane systems: apoprotein of the Folch-Lees proteolipid from beef-brain myelin.

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Ultimate tensile strength, percent elongation, tear strength, and Shore A hardness were evaluated. Quercetin at 5mg/kg showed little effect on diabetic osteopenia, while quercetin at 30 mg/kg and 50mg/kg could increase the decreased serum osteocalcin, serum alkaline phosphatase activity, and urinary deoxypyridinoline in diabetic rats. The expression level of FtsZ protein during the dedifferentiation and redifferentiation of explants of Nicotiana tobacum. Clinical experience based on 22 patients from 18 Spanish families. The current incidence of birth noroxin 400 mg precio defects among newborns and stillbirths of in our population is similar to those obtained by other studies performed in Brazil and in other underdeveloped countries.

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As part of the study, a topographic classification of PVR has been developed that is based flagyl tablet usage on the characteristic patterns of retinal distortion produced by the contraction of proliferative membranes on the retina or within the vitreous base. Using a newly developed direct binding assay with mass spectrometry technology (direct analysis in real-time time-of-flight mass spectrometry), we were able to show that compounds present in extracts of elderberry, cinnamon and green tea bind to and block HIV type-1 (HIV-1) infection in target cells. Sleep and circadian rhythm disturbances were more frequently noted in diabetic patients than in healthy controls. There is no/few systematic review or research addressing sexual dysfunction and their effect on serum prolactin level among different atypical antipsychotics in India. Experimental validation of EvoTSP on public available microarray datasets showed that the proposed solution significantly outperforms in terms of accuracy other relative expression algorithms and allows exploring much larger solution space. A six-residue LDLR signal, FDNPVY, is required for activity in TR, whereas a four-residue Man-6-PR signal, YSKV, is sufficient. EP was evaluated regarding the intraoperative and postoperative complications. Many applications such as ultrasonic cleaning or sonochemistry use the ability of bubbles to oscillate and drive liquid flow. Measuring estrogens and progestagens in humans: an overview of methods.

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We developed standardized protocols to a panel of tumor cell lines from different pathologies and attained efficient tumor cell aggregation by tuning hydrodynamic parameters. The transfemoral access remains the first choice for the treatment of patients with PAOD. A case is presented where there is bilateral symmetrical fusion of the mandibular lateral incisors and canines involving the primary and permanent dentition. Co-administration of non-carrier nanoparticles boosts antigen immune response without requiring protein conjugation. An essential property of visceral sensory afferents is to be able to alter their firing properties in response to changes in the microenvironment at the level of the sensory ending. There is also a need to develop and validate outcome measures for interventions to improve dignity. This indicates that the difference in survival among colorectal cancer patients from different social groups was probably not caused by unintentional differences in treatment factors related to surgery, and suggests that primary prevention of chronic diseases among the socially deprived might be one way to reduce social differences in prognosis. Our aim in this study was to identify the endoscopic anatomy of the anterior cranio-vertebral junction to be able to perform minimal invasive endoscopic surgical procedures to this region (such as dens resection) safely with better postoperative performance of the patients. Hippocampal volume reductions were detected in subjects with first episode (FE) of psychosis, in all young adults and in adolescents at HR of schizophrenia.

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