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Roksolit (Roxithromycin)

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Roksolit is part of the family of medications known as macrolide antibiotics and is commonly used in the treatment of bacterial infections. Roksolit is generically prescribed as roxithromycin and can cause life threatening heart complications in patients who also take pimozide, astemizole, cisapride, ergot medications, and terfenadine. Roksolit is an ineffective treatment option for patients suffering from infections caused by a virus or bacterium.

Other names for this medication:
Aristomycin, Asmetic, Assoral, Azuril, Bazuctril, Bicofen, Biostatik, Cadithro, Dorolid, Elrox, Erybros, Floxid, Ladlid, Macrolid, Macrosil, Nirox, Odonticina, Overal, Pedilid, Pedrox, Redotrin, Remora, Renicin, Rokilide, Roksimin, Roksolit, Rolexit, Romac, Rotramin, Roxacine, Roxithromycin, Roxithromycine, Roxithromycinum, Rulid

Similar Products:
Biaxin, Chloromycetin, Myambutol, Rulide, Noroxin, Suprax, Zithromax, Sumycin, Terramycin

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Also known as: Roxithromycin


Roksolit is a semi-synthetic macrolide antibiotic. It is used to treat respiratory tract, urinary and soft tissue infections. Roksolit is derived from erythromycin, containing the same 14-membered lactone ring. However, an N-oxime side chain is attached to the lactone ring. It is also currently undergoing clinical trials for the treatment of male-pattern hair loss.

Roksolit is available under several brandnames. Roksolit is not available in the United States. Roksolit is available in Australia, Israel and New Zealand. Roksolit has also been tested to possess antimalarial activity.

Roksolit prevents bacteria from growing, by interfering with their protein synthesis. Roksolit binds to the subunit 50S of the bacterial ribosome, and thus inhibits the synthesis of peptides. Roksolit has similar antimicrobial spectrum as erythromycin, but is more effective against certain gram-negative bacteria, particularly Legionella pneumophila.


Roksolit is typically prescribed for a period of 7 to 14 days and patients should take the medication for as long as it has been prescribed to prevent the infection from returning even if they become asymptomatic. Patients should not however, take doses larger than has been prescribed as this can result in an overdose. Overdosing requires immediate medical intervention and may present with symptoms which include abdominal pain, nausea, diarrhea, vomiting, and a general and prolonged feeling of illness.


If you overdose Generic Roksolit and you don't feel good you should visit your doctor or health care provider immediately.


Keep your tablets in the blister pack until it is time to take them. If you take the tablets out of the blister pack they may not keep well.

Keep the medicine in a cool, dry place where the temperature stays below 25 degrees C.

Do not store it or any other medicine in the bathroom, near a sink or on windowsill.

Do not leave it in the car. Heat and damp can destroy some medicines.

Keep it where children cannot reach it. A locked cupboard at least one-and-a-half metres above the ground is a good place to store medicines.

Side effects

The most common side effects associated with Roksolit are:

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Side effect occurrence does not only depend on medication you are taking, but also on your overall health and other factors.


The safety of roxithromycin has not been demonstrated in patients with impaired hepatic or renal function. Caution should be exercised if roxithromycin is administered to patients with impaired hepatic or renal function. If administered to patients with severe impaired hepatic function (eg. hepatic cirrhosis with jaundice and/or ascites), consideration should be given to reducing the daily dosage to half the usual dosage.

Prolonged or repeated use of antibiotics including roxithromycin may result in superinfection by resistant organisms. In the event of superinfection, roxithromycin should be discontinued and appropriate therapy instituted.

When indicated, incision, drainage or other appropriate surgical procedures should be performed in conjunction with antibiotic therapy.

Antibiotic associated pseudomembranous colitis has been reported with many antibiotics. A toxin produced by Clostridium difficile appears to be the primary cause. The severity of the colitis may range from mild to life threatening. It is important to consider this diagnosis in patients who develop diarrhoea or colitis in association with antibiotic use (this may occur up to several weeks after cessation of antibiotic therapy). Mild cases usually respond to drug discontinuation alone. However, in moderate to severe cases, appropriate therapy with a suitable oral antibacterial agent effective against Clostridium difficile should be considered. Fluids, electrolytes and protein replacement therapy should be provided when indicated.

Roxithromycin, like erythromycin, has been shown in vitro to elicit a concentration - dependent lengthening in cardiac action potential duration. Such an effect is manifested only at supra – therapeutic concentrations. Accordingly, the recommended doses should not be exceeded. In certain conditions macrolides, including roxithromycin, have the potential to prolong the QT interval. Therefore roxithromycin should be used with caution in patients with congenital prolongation of the QT interval, with ongoing proarrhythmic conditions (ie uncorrected hypokalemia or hypomagnesaemia, clinically significant bradycardia), and in patients receiving Class IA and III antiarrhythmic agents.

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Peroxovanadium compounds, known to be insulinomimetic agents and protein tyrosine phosphatase inhibitors, are cytotoxic to the cells, they activate JNK and down-regulate MPK-1. These results support the concept that adipocytes participate in a deleterious crosstalk with cancer cells to support tumour progression, that might be amplified in obesity conditions and explain the poor prognosis of cancers observed in this subset of patients. We thus developed a new strategy based on recombinant viruses expressing tagged viral proteins to capture both direct and indirect physical binding partners during infection. The work bridges the gap between nanoscale materials and macroscopic applications. Remission and recurrence of chronic obstructive lung disease in air pollution caused lung disease patients in the Yokkaichi area. Analysis of loop boundaries using different local structure assignment methods. This treatment leads to clinically significant sleep improvements within 6 weeks and these improvements appear to endure through 6 months of follow-up.

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Activation of beta-catenin signalling increases StarD7 gene expression in JEG-3 cells. During steady swimming, females with high RA had increased tail beat amplitudes, indicating increased swimming costs. Donovani Specific Antigen for Serodiagnosis of Visceral Leishmaniasis. Internalization and degradation of insulin by a human insulin receptor-v-ros hybrid in Chinese hamster ovary cells. These results identify several interactive target sites within the hippocampus, extended amygdala and cortical regions.

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Biochemical, metabolic and immune correlates of seasonal variation in violent suicide: a chronoepidemiologic study. The experimental steps to adsorb thiourea molecules on a copper substrate are described in detail. A greater recovery in cell survival with decreasing dose per fraction, or increasing fraction number, was observed for primitive CAFC day-28 and day-35 than for CAFC day-6 and day-12 (colony-forming unit (CFU)-granulocyte macrophage and CFU-spleen day-12 equivalents). Post glucose challenge, there was a significant increase in blood glucose levels and insulin level in the leptin treated rats. The solution of this problem lies on the field of artificial intelligence. There will thus be a balance between biological and chemical control in most systems. Vasa in spermatogonia concentrates in small areas of the cytoplasm and is surrounded by mitochondria, which is reminiscent of MC. Mental health locus of control in 77 first-degree relatives of agoraphobic, agoraphobic and major depressed (comorbid), and depressed inpatients were studied.

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Analytical utility of quadrupole time-of-flight mass spectrometry for the determination of pesticide residues in comparison with an optimized column high-performance liquid chromatography/tandem mass spectrometry method. Models are used to estimate the current maximum daily and annual average load, to estimate the contribution from different nonpoint sources, and to develop scenarios for achieving the TMDL target. As the injection system we propose a programmed temperature vaporizer (PTV) where, in solvent vent mode, better results can be obtained than with the conventional split and splitless injection modes. Several other ancient reticulation events between the two European species and the other species of the section were supported by the posterior predictive checking method. The target compounds 3-5 represent a novel class of potent and selective CB1 receptor antagonists. Glial cell line-derived neurotrophic factor (GDNF) gene delivery protects dopaminergic terminals from degeneration. Natural occurrence of aflatoxin residues in fresh and sun-dried meat in Nigeria. Based on serial mortalities for England and Wales, the standardised mortality ratio of 84 for all leukaemias (observed 111, expected 132.3) was similar to that of 83 for all causes (observed 14 845, expected 17 918).

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Mechanisms of the protective action of neoton in immune heart diseases. Invadopodia are actin-rich structures that are formed on the ventral membrane of the cell and degrade extracellular matrix (ECM) by accumulation of matrix metalloproteinase (MMP). Due to poor response to medical therapy and high mortality in patients with PVOD, understanding the pathogenesis, differentiation with pulmonary arterial hypertension and the search for a new methods of treatment should be the key challenges for modern medicine. The balsam of Peru and the fragrance mix are among the leader allergens, and this should be can biaxin treat kidney infection considered during treatment. Maxillary sinus aspergillosis: diagnosis and differentiation of the pathogenesis based on computed tomography densitometry of sinus concretions. Recent studies indicate that reactive oxygen species are upregulated in tumors and can lead to aberrant induction of signaling networks that cause tumorigenesis and metastasis.

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Various methods have been studied as replacement of human landing catches (HLC) for mosquito sampling in entomological studies on malaria transmission. The ON of the anaemic group showed a reduced mean density of myelinated fibres when compared with the control group. Reflection on Professor Sir Magdi Yacoub: a pioneering cardiac surgeon. Diseases of the pleura continue to affect a large population of patients worldwide and in the United States. Larynx resistance was measured by the subglottic pressure value using the in situ isolated glottis technique. Although uveitis remains the third leading cause of preventable blindness in the US, the care and management of patients with uveitis and ocular inflammatory disease sit poised to make evolutionary if not revolutionary changes in the years ahead. The aim of this study was to provide a computational model to estimate the regions in which electrical stimulation will generate an action potential in the axons.

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