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Rolexit (Roxithromycin)

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Rolexit is indicated for the treatment of the following mild to moderately severe infections in children caused by or likely to be caused by susceptible micro-organisms: acute pharyngitis, acute tonsillitis and impetigo.

Other names for this medication:
Aristomycin, Asmetic, Assoral, Bazuctril, Biostatik, Cadithro, Claramid, Delos, Dorolid, Floxid, Infectoroxit, Makrodex, Odonticina, Overal, Pedrox, Ramivan, Remora, Rokilide, Rokithrid, Roksimin, Rolexit, Romac, Rossitrol, Roxacine, Roxithromycin, Roxithromycine, Roxithromycinum, Roxitromicina

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Also known as: Roxithromycin


Rolexit is a semi-synthetic macrolide antibiotic. It is used to treat respiratory tract, urinary and soft tissue infections. Rolexit is derived from erythromycin, containing the same 14-membered lactone ring. However, an N-oxime side chain is attached to the lactone ring. It is also currently undergoing clinical trials for the treatment of male-pattern hair loss.

Rolexit is available under several brandnames. Rolexit is not available in the United States. Rolexit is available in Australia, Israel and New Zealand. Rolexit has also been tested to possess antimalarial activity.

Rolexit prevents bacteria from growing, by interfering with their protein synthesis. Rolexit binds to the subunit 50S of the bacterial ribosome, and thus inhibits the synthesis of peptides. Rolexit has similar antimicrobial spectrum as erythromycin, but is more effective against certain gram-negative bacteria, particularly Legionella pneumophila.


Rolexit is typically prescribed for a period of 7 to 14 days and patients should take the medication for as long as it has been prescribed to prevent the infection from returning even if they become asymptomatic. Patients should not however, take doses larger than has been prescribed as this can result in an overdose. Overdosing requires immediate medical intervention and may present with symptoms which include abdominal pain, nausea, diarrhea, vomiting, and a general and prolonged feeling of illness.


If you overdose Generic Rolexit and you don't feel good you should visit your doctor or health care provider immediately.


Store at room temperature between 20 and 25 degrees C (68 and 77 degrees F) away from moisture, light and heat. Do not store in the bathroom. Keep in a tight, light-resistant container. Keep out of the reach of children.

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Side effect occurrence does not only depend on medication you are taking, but also on your overall health and other factors.


The safety of roxithromycin has not been demonstrated in patients with impaired hepatic or renal function. Caution should be exercised if roxithromycin is administered to patients with impaired hepatic or renal function. If administered to patients with severe impaired hepatic function (eg. hepatic cirrhosis with jaundice and/or ascites), consideration should be given to reducing the daily dosage to half the usual dosage.

Prolonged or repeated use of antibiotics including roxithromycin may result in superinfection by resistant organisms. In the event of superinfection, roxithromycin should be discontinued and appropriate therapy instituted.

When indicated, incision, drainage or other appropriate surgical procedures should be performed in conjunction with antibiotic therapy.

Antibiotic associated pseudomembranous colitis has been reported with many antibiotics. A toxin produced by Clostridium difficile appears to be the primary cause. The severity of the colitis may range from mild to life threatening. It is important to consider this diagnosis in patients who develop diarrhoea or colitis in association with antibiotic use (this may occur up to several weeks after cessation of antibiotic therapy). Mild cases usually respond to drug discontinuation alone. However, in moderate to severe cases, appropriate therapy with a suitable oral antibacterial agent effective against Clostridium difficile should be considered. Fluids, electrolytes and protein replacement therapy should be provided when indicated.

Roxithromycin, like erythromycin, has been shown in vitro to elicit a concentration - dependent lengthening in cardiac action potential duration. Such an effect is manifested only at supra – therapeutic concentrations. Accordingly, the recommended doses should not be exceeded. In certain conditions macrolides, including roxithromycin, have the potential to prolong the QT interval. Therefore roxithromycin should be used with caution in patients with congenital prolongation of the QT interval, with ongoing proarrhythmic conditions (ie uncorrected hypokalemia or hypomagnesaemia, clinically significant bradycardia), and in patients receiving Class IA and III antiarrhythmic agents.

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Empowerment in the field of health promotion: recognizing challenges in working toward equity. Complete local excision without entering the tarsus produced relief of symptoms. In two patients, avascular changes were recognized in the proximal pole in preoperative radiographs or MRI. Our results suggest that finite-size, columnar neural circuits may play an important role in generating neural oscillations around the critical states, potentially enabling functional advantages of both SOCs and oscillations for sensitive response to transient stimuli. The overall therapeutic efficacy of lofepramine is comparable to that of imipramine, amitriptyline, clomipramine, maprotiline and mianserin in patients with depression of varying severity, and coexisting anxiety. As well as being amenable to existing in vivo targeting strategies already in use for viruses and liposomes, this novel approach offers the added advantages of in vivo safety and low immunogenicity.

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The role of PTEN-induced kinase 1 in mitochondrial dysfunction and dynamics. In turn, the MSs modulated both visually induced GBS and the speed of visually triggered behavioral responses. For each physical examination element, the authors define the finding and its prevalence among pediatric patients with obesity, discuss the importance and relevance of the finding, describe known techniques to assess severity, and review evidence regarding the need for additional evaluation. (Zingiberaceae) that protect PC12 rat pheochromocytoma and normal human umbilical vein endothelial cells from betaA(1-42) insult. Interaction of Escherichia coli O157:H7 with leafy green produce. A commercially available uric acid monitoring system that is chemically modified to reduce interference was evaluated via clinical evaluation for its performance and interference as compared to a centralized laboratory instrument. The politics of protection: aid, human rights discourse, and power relations in Kyaka II settlement, Uganda. Inhaled fluorescent magnetic nanoparticles induced extramedullary hematopoiesis in the spleen of mice. In the present paper we describe a novel nucleocytoplasmic transport assay that has enabled us to study the nuclear distribution of nucleoplasmin following its transport into the nucleus. Continuous subcutaneous desferrioxamine injection in primary idiopathic hemochromatosis with macrocytic anemia.

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Advanced photochemical oxidation of emergent micropollutants: carbamazepine. Differential concentration of Technetium-99 (99Tc) in common intertidal molluscs with different food habits. Through the use of a panel of different immunocytochemical markers these pAP N-immunopositive cells were characterized as ED 1-positive, most likely hematogenous macrophages. Mesenteric cysts have diverse presentation and arise from a variety of sites. Chondrocyte viability, phenotype, and extracellular suprax 400 mg coupon matrix composition of growth plate cartilage was assessed. The drugs were injected intraperitoneally once a day for 6 or 20 days. Breast-specific gamma imaging (BSGI) is used less frequently although it is of similar utility and lower cost.

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