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Synclar (Clarithromycin)
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Synclar

Synclar is used to treat certain bacterial infections, such as pneumonia (a lung infection), bronchitis (infection of the tubes leading to the lungs), and infections of the ears, sinuses, skin, and throat. Synclar is used to treat and prevent disseminated Mycobacterium avium complex (MAC) infection [a type of lung infection that often affects people with human immunodeficiency virus (HIV)].

Other names for this medication:
Abbotic, Bicrolid, Binoclar, Bremon, Ciclinil, Clabel, Clacine, Clamycin, Clarimed, Clarimycin, Clariston, Claritab, Claritron, Claritrox, Clarocin, Clarytas, Clasine, Clatic, Cleanomisin, Cleron, Fromilid, Geromycin, Klabax, Klarifor, Klarigen, Klarimax, Klarit, Klarithrin, Klazidem, Krobicin, Likmoss, Macrobid, Macromicina, Mononaxy, Rolacin, Rolicytin, Uniklar, Zeclar

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Also known as: Clarithromycin

Description

Synclar (generic name: clarithromycin; brand names include: Maclar / Klaricid / Klacid / Clarimac / Claribid) is used to treat many different types of bacterial infections affecting the skin and respiratory system, including: Strep throat, Pneumonia, Sinusitis (inflamed sinuses), Tonsillitis (inflamed tonsils), Acute middle ear infections, Acute flare-ups of chronic bronchitis.

It also is used to treat and prevent disseminated Mycobacterium avium complex (MAC) infection [a type of lung infection that often affects people with human immunodeficiency virus (HIV)]. It is used in combination with other medications to eliminate H. pylori, a bacteria that causes ulcers.

It also is used sometimes to treat other types of infections including Lyme disease (an infection that may develop after a person is bitten by a tick), crypotosporidiosis (an infection that causes diarrhea), cat scratch disease (an infection that may develop after a person is bitten or scratched by a cat), Legionnaires' disease (a type of lung infection), and pertussis (whooping cough; a serious infection that can cause severe coughing). It is also sometimes used to prevent heart infection in patients having dental or other procedures.

This medication may be prescribed for other uses; ask your doctor or pharmacist for more information.

Synclar works by stopping the growth of or killing sensitive bacteria by interfering with their protein synthesis.

Dosage

The recommended daily dosage is 15 mg/kg/day divided every 12 hours for 10 days (up to the adult dose). Refer to dosage regimens for mycobacterial infections in pediatric patients for additional dosage information.

For the treatment of disseminated infection due to Mycobacterium avium complex (MAC), Synclar Filmtab and Synclar Granules are recommended as the primary agents. Synclar Filmtab and Synclar Granules should be used in combination with other antimycobacterial drugs (e.g. ethambutol) that have shown in vitro activity against MAC or clinical benefit in MAC treatment.

For treatment and prophylaxis of mycobacterial infections in adults, the recommended dose of Synclar is 500 mg every 12 hours.

For treatment and prophylaxis of mycobacterial infections in pediatric patients, the recommended dose is 7.5 mg/kg every 12 hours up to 500 mg every 12 hours.

Synclar therapy should continue if clinical response is observed. Synclar can be discontinued when the patient is considered at low risk of disseminated infection.

Overdose

Overdose symptoms may include severe stomach pain, nausea, vomiting, or diarrhea.

Storage

Store at room temperature between 20 and 25 degrees C (68 and 77 degrees F) away from moisture and heat. Keep container tightly closed. Protect from light. Throw away any unused medicine after the expiration date. Keep out of the reach of children.

Side effects

The most common side effects associated with Synclar are:

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Side effect occurrence does not only depend on medication you are taking, but also on your overall health and other factors.

Contraindications

Concomitant cisapride, pimozide, ergots, HMG-CoA reductase inhibitors extensively metabolized by CYP3A4 (lovastatin or simvastatin). History of QT prolongation or ventricular cardiac arrhythmia (including torsades de pointes). Concomitant colchicine (in renal or hepatic impairment). Cholestatic jaundice/hepatic dysfunction with prior clarithromycin use.

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Posterior fossa arterio-venous malformations: current multimodal treatment strategies and results. Qualitative analysis of the level of cross-protection between epidemic waves of the 1918-1919 influenza pandemic. We propose kernel parallel analysis (kPA) for automatic kernel scale and model order selection in Gaussian kernel principal component analysis (KPCA). Much interest has recently focused on the study of lens membrane structure and function, mainly because membrane dysfunction may be associated with cataract formation. Of these 125 patients 49 were Ta, 76 were T1, 58 were low grade carcinoma, 67 were high grade carcinoma and 30 were not found presence of muscle tissue in initial resected sample in patients with T1 stage. The AmpliChip: A Review of its Analytic and Clinical Validity and Clinical Utility.

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A qualitative study of the attitudes of members of a developing community towards their dogs and veterinary services. Subtype diversity was higher in Buenos Aires than in Rio de Janeiro and two new subtypes were described for the first time. This finding was further validated by pulse-chase experiments using 35S-methionine metabolic labeling. A comprehensive compilation and alignment of histones and histone genes. The proposed method, which differs from the existing results in the literature, shows that network models may admit a periodic solution which is globally exponentially stable via proper impulsive control strategies even if it is originally unstable or divergent. From studies on the dual 5AR inhibitor dutasteride, the drug produces a biochemical response in some men who progressed under androgen-deprivation therapy, and is generally well tolerated. This review summarizes important themes that have emerged regarding the roles of autophagy in C. We present a rare case of popliteal A-V fistula following TKR and discuss the probable etiology and the management. Differentiation of Aedes aegypti and Aedes albopictus (Diptera: Culicidae) with egg surface morphology and morphometrics using scanning electron microscopy.

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There are several options for correcting astigmatism at the time of cataract surgery, which include using the cataract incision or astigmatic keratotomy to counteract pre-existing astigmatism, or using a toric intraocular lens (Toric IOL). Segmental dilatation of the small bowel is a rare congenital abnormality that occurs mainly in children and produces significant nonspecific symptoms. With the development of abdominal echotomography and computed tomography, the abdominal aortic aneurysm is no longer explored by arteriography alone. Mutations of the Ectodysplasin-A (EDA) gene are generally associated with the syndrome hypohidrotic ectodermal dysplasia (MIM 305100), but they can also manifest as selective, non-syndromic tooth agenesis (MIM300606). Genetically labeled isolated cardioblasts express cardiac transcription factors and sarcomeric proteins, exhibit spontaneous contractions, and form mature cardiomyocytes in vivo after injection into unlabeled recipient hearts.

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Prospective clinical studies are required to ascertain whether integrating mechanical parameters with medical imaging can improve our ability to identify patients at highest risk of rapid disease progression or sudden cardiac events. Prostate radiation therapy: in vivo measurement of the dose delivered by kV-CBCT. We constructed heterozygous deletions of one copy of essential genes in diploid cells and purified spores containing the deletion allele. No statistical difference in adjustments was noted between the two groups. Laparoscopic posterior fundoplication in gastroesophageal reflux: mid-term results. The overall approach to classifying cattle-owning communities in terms of AAT vulnerability was based on the selection of key variables collected through field surveys in five sub-Saharan Africa countries followed by a formal Multiple Correspondence Analysis (MCA) to identify factors explaining the variations between areas.

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Do dietary fatty acids affect the interactions among macrophages, endothelial lesions, and thrombosis?. Test for respiratory and asthma control in kids (TRACK): a validated control tool for preschool-aged children. At present, adrenergic receptors are divided into three main groups, depicted as alpha 1, alpha 2 a beta receptors. To broaden our understanding of the clinical potential for squalamine, this agent was evaluated in nu/nu mouse xenograft models using the chemoresistant MV-522 human non-small cell lung carcinoma and the SD human neuroblastoma lines. Some level of the dissociated dimeric form was observed in the K315L mutant, but it was not observed for the K315A and E267L/K315L mutants. As a result we were able to show that the pocket depth correlates with the periotest values for all tooth groups. Effect of gonadectomy on growth and GH responsiveness in dwarf rats. Immunochemical specificity of placental NADPH cytochrome c (P-450) reductase in neoplastic and non-neoplastic human tissue.

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Highlighting implementation issues and potential responses to these should be of interest to decision makers implementing PBMA and other evidence-informed practices. Neuroparalytic snake bite is a common emergency situation encountered in India. In these patients, specific and if warranted, invasive diagnostic procedures followed by early vigorous therapeutic intervention should be considered. In contrast, viremia in GT 3 infected mice developed more slowly and displayed lower titres in all analysed tissues as compared to GT 1. In the present study, the authors examined whether CBT tested under well-controlled conditions generalizes to less-controlled, real-world circumstances. A Well-Kept Treasure at Depth: Precious Red Coral Rediscovered in Atlantic Deep Coral Gardens (SW Portugal) after 300 Years. Violence against omnicef generic name new graduated nurses in clinical settings: A qualitative study. Twenty-three children suffering from Duchenne/Becker muscular dystrophy (DMD/BMD) in Singapore were analysed using the multiplex polymerase chain reaction (PCR) technique.

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Few studies have been performed on the laparoscopic findings associated with this disease, and the present study was intended to assess the usefulness of laparoscopy for the diagnosis and staging of PSC. We recommend this combination for neonates with both gastroschisis and intestinal atresia. Cell proliferation dynamics in regeneration of the operculum head appendage in can omnicef treat tooth infection the annelid Pomatoceros lamarckii. Intracerebral hemorrhage after treatment with intravenous recombinant tissue-type plasminogen activator for ischemic stroke can occur in local relation to the infarct, as well as in brain areas remote from infarcted tissue. The comorbidity of anxiety with allergies, cataracts, arthritis and lung disease resulted in poorer self-rated physical and/or mental health after adjusting for confounding variables. Even though main conclusions are based on one global-regional model downscaling, this approach provides valuable information for implementing proper and diverse adaptation measures in the Argentinean viticultural regions. Epidemiological and intervention studies on the effect of marine polyunsaturated fatty acids on blood pressure. In northern Sweden, consumption of both filtered and boiled coffee is common. Thus, proliferating U937, TUR, and retrodifferentiated U937 cells exhibited a 4.3-fold, 5.8-fold, and 4.3-fold proteasome activation within 15 minutes after adriamycin treatment, respectively. Although many successful physiological and genetic approaches have been taken to conclude the key virulence determinants encoded by this organism, the total number of uncharacterized reading frames observed within the S.

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Reliability of the amplitude of the return-sweep velocity of eye movements during reading. Lastly, subjects modified their recovery response to this task within 12 disturbances. Arterial wall thickening, compensatory arterial enlargement and a preserved arterial lumen characterize subclinical atherosclerosis. To better understand the incidence and epidemiological features of ALL in Shanghai, we conducted a retrospective survey based on the database from the Shanghai Center for Disease Control and Prevention (CDC) and the medical records in all large-scale hospitals in Shanghai, especially those 30 major hospitals with hematology department. Of these 25 bones, 5 had been labeled in vivo with fluorochrome markers. A different definition of schizophrenia probably accounts for the greater part of the different results in this and previous studies. However, further studies on the isolation and characterization of active constituents of PECQ, which can cross the placental barrier and are responsible for the bone anabolic activity are warranted.

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