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Synclar (Clarithromycin)

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Synclar is used to treat certain bacterial infections, such as pneumonia (a lung infection), bronchitis (infection of the tubes leading to the lungs), and infections of the ears, sinuses, skin, and throat. Synclar is used to treat and prevent disseminated Mycobacterium avium complex (MAC) infection [a type of lung infection that often affects people with human immunodeficiency virus (HIV)].

Other names for this medication:
Abbotic, Bicrolid, Binoclar, Bremon, Ciclinil, Clabel, Clacine, Clamycin, Clarimed, Clarimycin, Clariston, Claritab, Claritron, Claritrox, Clarocin, Clarytas, Clasine, Clatic, Cleanomisin, Cleron, Fromilid, Geromycin, Klabax, Klarifor, Klarigen, Klarimax, Klarit, Klarithrin, Klazidem, Krobicin, Likmoss, Macrobid, Macromicina, Mononaxy, Rolacin, Rolicytin, Uniklar, Zeclar

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Also known as: Clarithromycin


Synclar (generic name: clarithromycin; brand names include: Maclar / Klaricid / Klacid / Clarimac / Claribid) is used to treat many different types of bacterial infections affecting the skin and respiratory system, including: Strep throat, Pneumonia, Sinusitis (inflamed sinuses), Tonsillitis (inflamed tonsils), Acute middle ear infections, Acute flare-ups of chronic bronchitis.

It also is used to treat and prevent disseminated Mycobacterium avium complex (MAC) infection [a type of lung infection that often affects people with human immunodeficiency virus (HIV)]. It is used in combination with other medications to eliminate H. pylori, a bacteria that causes ulcers.

It also is used sometimes to treat other types of infections including Lyme disease (an infection that may develop after a person is bitten by a tick), crypotosporidiosis (an infection that causes diarrhea), cat scratch disease (an infection that may develop after a person is bitten or scratched by a cat), Legionnaires' disease (a type of lung infection), and pertussis (whooping cough; a serious infection that can cause severe coughing). It is also sometimes used to prevent heart infection in patients having dental or other procedures.

This medication may be prescribed for other uses; ask your doctor or pharmacist for more information.

Synclar works by stopping the growth of or killing sensitive bacteria by interfering with their protein synthesis.


The recommended daily dosage is 15 mg/kg/day divided every 12 hours for 10 days (up to the adult dose). Refer to dosage regimens for mycobacterial infections in pediatric patients for additional dosage information.

For the treatment of disseminated infection due to Mycobacterium avium complex (MAC), Synclar Filmtab and Synclar Granules are recommended as the primary agents. Synclar Filmtab and Synclar Granules should be used in combination with other antimycobacterial drugs (e.g. ethambutol) that have shown in vitro activity against MAC or clinical benefit in MAC treatment.

For treatment and prophylaxis of mycobacterial infections in adults, the recommended dose of Synclar is 500 mg every 12 hours.

For treatment and prophylaxis of mycobacterial infections in pediatric patients, the recommended dose is 7.5 mg/kg every 12 hours up to 500 mg every 12 hours.

Synclar therapy should continue if clinical response is observed. Synclar can be discontinued when the patient is considered at low risk of disseminated infection.


Overdose symptoms may include severe stomach pain, nausea, vomiting, or diarrhea.


Store at room temperature between 20 and 25 degrees C (68 and 77 degrees F) away from moisture and heat. Keep container tightly closed. Protect from light. Throw away any unused medicine after the expiration date. Keep out of the reach of children.

Side effects

The most common side effects associated with Synclar are:

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A community acquired pneumonia case caused by Ralstonia pickettii. Magnetic resonance imaging (MRI) was performed to exclude a pathological cause in view of the unusual fracture site, which confirmed the plain radiographic findings and additionally demonstrated a stress reaction in the proximal radius. Four tasks were investigated, some requiring the observer to discriminate between horizontal and vertical grouping, and some requiring the observer to merely detect the presence or absence of grouping. XAS and XFM studies of selenium and copper speciation and distribution in the kidneys of selenite-supplemented rats. They presented also the use of the same technique in the luxations of permanent incisors, and compared the results. However, extensive imaging did not detect primary tumor anywhere.

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Posterior fossa arterio-venous malformations: current multimodal treatment strategies and results. Qualitative analysis of the level of cross-protection between epidemic waves of the 1918-1919 influenza pandemic. We propose kernel parallel analysis (kPA) for automatic kernel scale and model order selection in Gaussian kernel principal component analysis (KPCA). Much interest has recently focused on the study of lens membrane structure and function, mainly because membrane dysfunction may be associated with cataract formation. Of these 125 patients 49 were Ta, 76 were T1, 58 were low grade carcinoma, 67 were high grade carcinoma and 30 were not found presence of muscle tissue in initial resected sample in patients with T1 stage. The AmpliChip: A Review of its Analytic and Clinical Validity and Clinical Utility.

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laryngeus is a nematode in which the male and female are permanently joined in copula, producing a distinctive Y shape. Preclinical efficacy of cystatin C to target the oncogenic activity of transforming growth factor Beta in breast cancer. Adaptation themes for prenatal care delivered by public health nurses. Although generally suppressed in most healthy tissues by a variety of epigenetic processes and antiviral mechanisms, there is evidence that some members of this family are (at least partly) still active - particularly in certain stem cells and various tumors. Phylogenetic studies and sequence analyses indicated that LDHA, LDHB and LDH6B genes are present in all mammalian genomes examined, including a monotreme species (platypus), whereas the LDHC gene may have arisen more recently in marsupial mammals. The mechanisms that protect the genomic DNA from the undesired action of deaminases are unknown. Polyalanine expansions in the poly(A)-binding protein nuclear 1 (PABPN1) gene causes oculopharyngeal muscular dystrophy (OPMD). However, nucleic acids face several obstacles in the creation of effective nucleic acid drugs.

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A qualitative study of the attitudes of members of a developing community towards their dogs and veterinary services. Subtype diversity was higher in Buenos Aires than in Rio de Janeiro and two new subtypes were described for the first time. This finding was further validated by pulse-chase experiments using 35S-methionine metabolic labeling. A comprehensive compilation and alignment of histones and histone genes. The proposed method, which differs from the existing results in the literature, shows that network models may admit a periodic solution which is globally exponentially stable via proper impulsive control strategies even if it is originally unstable or divergent. From studies on the dual 5AR inhibitor dutasteride, the drug produces a biochemical response in some men who progressed under androgen-deprivation therapy, and is generally well tolerated. This review summarizes important themes that have emerged regarding the roles of autophagy in C. We present a rare case of popliteal A-V fistula following TKR and discuss the probable etiology and the management. Differentiation of Aedes aegypti and Aedes albopictus (Diptera: Culicidae) with egg surface morphology and morphometrics using scanning electron microscopy.

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Prospective clinical studies are required to ascertain whether integrating mechanical parameters with medical imaging can improve our ability to identify patients at highest risk of rapid disease progression or sudden cardiac events. Prostate radiation therapy: in vivo measurement of the dose delivered by kV-CBCT. We constructed heterozygous deletions of one copy of essential genes in diploid cells and purified spores containing the deletion allele. No statistical difference in adjustments was noted between the two groups. Laparoscopic posterior fundoplication in gastroesophageal reflux: mid-term results. The overall approach to classifying cattle-owning communities in terms of AAT vulnerability was based on the selection of key variables collected through field surveys in five sub-Saharan Africa countries followed by a formal Multiple Correspondence Analysis (MCA) to identify factors explaining the variations between areas.

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Do dietary fatty acids affect the interactions among macrophages, endothelial lesions, and thrombosis?. Test for respiratory and asthma control in kids (TRACK): a validated control tool for preschool-aged children. At present, adrenergic receptors are divided into three main groups, depicted as alpha 1, alpha 2 a beta receptors. To broaden our understanding of the clinical potential for squalamine, this agent was evaluated in nu/nu mouse xenograft models using the chemoresistant MV-522 human non-small cell lung carcinoma and the SD human neuroblastoma lines. Some level of the dissociated dimeric form was observed in the K315L mutant, but it was not observed for the K315A and E267L/K315L mutants. As a result we were able to show that the pocket depth correlates with the periotest values for all tooth groups. Effect of gonadectomy on growth and GH responsiveness in dwarf rats. Immunochemical specificity of placental NADPH cytochrome c (P-450) reductase in neoplastic and non-neoplastic human tissue.

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Association of single nucleotide polymorphisms in PIM-1 gene with the risk of Korean lung cancer. A longitudinal qualitative study was conducted incorporating semi-structured interviews and thematic analysis. Bullatacin-induced apoptosis was antagonized by z-LEHD-fmk, a caspase-9 inhibitor, but not by z-IETD-fmk, a caspase-8 inhibitor. The aim of this study was to evaluate the effects of propofol on glucose metabolism and insulin secretion during intravenous glucose tolerance test (IVGTT) in rhesus monkey. The objective of the present study is to identify proteins that change in the extent of the modification with O-linked N-acetylglucosamine (O-GlcNAcylation) in the kidney from diabetic model Goto cleocin 150 mg cap -Kakizaki (GK) rats, and to discuss the relation between O-GlcNAcylation and the pathological condition in diabetes. Hepatic aniline hydroxylase showed the same behaviour as intestinal UDP-glucuronyl transferase. Mitral valve prolapse associated with partial absence of commissural chordal insertion: report of two cases. Eighteen finger pulp defects were reconstructed using a homodigital dorsal middle phalangeal neurovascular island flap procedure based on a single neurovascular pedicle preserving the length of the finger.

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Although ET continues to be defined by the presence of nonreactive thrombocythemia that is not accounted for by another chronic myeloid disorder, recent studies of clonality and other laboratory parameters have suggested clinically relevant biologic heterogeneity among affected patients. The new surgery can be performed on an outpatient basis and allows for the continuation of CAPD, thereby avoiding the cost associated with inpatient admission and interim hemodialysis. Cochrane schizophrenia reviews influence on policy and practice: an earthquake zone. Moreover, the release occurred in a short period of time upon brief exposure to its phase transition temperature. To clarify the role of superoxide dismutase (SOD) in this ischemic tolerance, we immunohistochemically investigated the alterations in copper-zinc SOD (CuZnSOD) and manganese SOD (Mn-SOD) in the gerbil hippocampus following 3-min ischemia with or without the first mild ischemia. Seroepidemiological survey of helminthic parasites of stray dogs in Sari City, northern Iran. Stimulation of the PI3K/Akt/mTOR and Ras/Raf/MEK/ERK pathways enhances growth, survival, can i take 4 flagyl pills at once and metabolism of cancer cells. The phenomenology of the psychotic state is often pleomorphic, with abnormal mood, paranoid delusions and hallucinations, with some clouding of consciousness or no evidence of impaired consciousness. Chemotherapy is the mainstay treatment for advanced non-small cell lung cancer (NSCLC).

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Retrospective population-based study of 175,298 NSCLC patients diagnosed histologically or cytologically from the statewide California Cancer Registry from 1989 to 2006. Twelve subjects were awakened four times in each of two experimental nights and alternately asked to recall tetracycline types of antibiotics , with or without concurrent verbalization, MSE contents preceding the awakening. In fact, brain cancer stem cells (BCSCs) have been isolated from brain tumor tissue and brain tumor cell lines by using neural stem cell culture methods and isolation methods for side population (SP) cells, which have high drug-efflux capacity. Late arterial occlusion was defined as occlusion occuring 72 hours after initial manifestation of the patient complaints related to the affected lower extremity. This is, to our knowledge, the first evidence for a global role of proteolysis in bacterial cell cycle control. The tissue concentrations of aspartate were also significantly lower in growth retarded fetuses than normally grown littermates. Turbot fish ELS proved to be an excellent model for the study of ecotoxicity of contaminants in seawater.

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Of these 17 patients, 11 were treated conservatively and all died. Based on evidence emerging from studies of intrinsic and extrinsic connectivity, transcranial magnetic stimulation, functional neuroimaging, and experimental studies in animals and humans, the authors propose 2 distinct patterns of reorganization that differentially engage ipsilesional and contralesional PMC. Testing this hypothesis, we found that intraventricular administration of recombinant human BDNF (rhBDNF) to adult rats with transections of the fimbria significantly reduces axotomy-induced degenerative changes of the cholinergic cells in the basal forebrain. The C-terminal region of HPNAP activates neutrophils and promotes their adhesion to endothelial cells. The anti-cancer agent paclitaxel (Taxol) stabilizes microtubules leading to G2/M cell cycle arrest and apoptotic cell death. Accelerated partial breast irradiation with IMRT: new technical approach and para que sirve el flagyl metronidazol 500 mg interim analysis of acute toxicity in a phase III randomized clinical trial. Cell proliferation was tested by methyl thiazolyl tetrazolium (MTT) assay. Tissue expansion for correction of male pattern baldness has not gained wide acceptance by patients or surgeons because of the substantial albeit temporary deformity of the expansion.

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Highlighting implementation issues and potential responses to these should be of interest to decision makers implementing PBMA and other evidence-informed practices. Neuroparalytic snake bite is a common emergency situation encountered in India. In these patients, specific and if warranted, invasive diagnostic procedures followed by early vigorous therapeutic intervention should be considered. In contrast, viremia in GT 3 infected mice developed more slowly and displayed lower titres in all analysed tissues as compared to GT 1. In the present study, the authors examined whether CBT tested under well-controlled conditions generalizes to less-controlled, real-world circumstances. A Well-Kept Treasure at Depth: Precious Red Coral Rediscovered in Atlantic Deep Coral Gardens (SW Portugal) after 300 Years. Violence against omnicef generic name new graduated nurses in clinical settings: A qualitative study. Twenty-three children suffering from Duchenne/Becker muscular dystrophy (DMD/BMD) in Singapore were analysed using the multiplex polymerase chain reaction (PCR) technique.

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Few studies have been performed on the laparoscopic findings associated with this disease, and the present study was intended to assess the usefulness of laparoscopy for the diagnosis and staging of PSC. We recommend this combination for neonates with both gastroschisis and intestinal atresia. Cell proliferation dynamics in regeneration of the operculum head appendage in can omnicef treat tooth infection the annelid Pomatoceros lamarckii. Intracerebral hemorrhage after treatment with intravenous recombinant tissue-type plasminogen activator for ischemic stroke can occur in local relation to the infarct, as well as in brain areas remote from infarcted tissue. The comorbidity of anxiety with allergies, cataracts, arthritis and lung disease resulted in poorer self-rated physical and/or mental health after adjusting for confounding variables. Even though main conclusions are based on one global-regional model downscaling, this approach provides valuable information for implementing proper and diverse adaptation measures in the Argentinean viticultural regions. Epidemiological and intervention studies on the effect of marine polyunsaturated fatty acids on blood pressure. In northern Sweden, consumption of both filtered and boiled coffee is common. Thus, proliferating U937, TUR, and retrodifferentiated U937 cells exhibited a 4.3-fold, 5.8-fold, and 4.3-fold proteasome activation within 15 minutes after adriamycin treatment, respectively. Although many successful physiological and genetic approaches have been taken to conclude the key virulence determinants encoded by this organism, the total number of uncharacterized reading frames observed within the S.

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Collagen-based biomaterials have found various applications in the biomedical field. Self-assembled monolayers (SAMs) of Raman reporter molecules adsorbed to the surface of metal nanoparticles are labelling agents for the selective detection of biomolecules by surface-enhanced Raman scattering (SERS). Utilizing structure-based drug design, a 4-aminoimidazole heterocyclic core was synthesized as a replacement for a 2-aminothiazole due to potential metabolically mediated toxicity. The material consisted of 31 dry skulls of modern Japanese males from the Museum of the University of Tokyo. This condition has an enormous clinical significance because in a very short interval and in a silent manner can cause complete and irreversible damage to the upper urinary tract. Isoquinolines, beta-carbolines and alcohol drinking: involvement of opioid and dopaminergic mechanisms. Moreover, whereas the control group demonstrated greater recruitment of prefrontal and parietal areas during perception of integrated forms compared to random stimuli, the schizophrenia group demonstrated greater recruitment of frontal regions during perception of random stimuli. The International Academic Nursing Alliance (IANA): a resource for global nursing knowledge exchange. Risk of adverse pregnancy outcomes in women with mild chronic hypertension before 20 weeks of gestation. The sites differed in proximity to the main channel for tidal intrusion and in several edaphic parameters.

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Reliability of the amplitude of the return-sweep velocity of eye movements during reading. Lastly, subjects modified their recovery response to this task within 12 disturbances. Arterial wall thickening, compensatory arterial enlargement and a preserved arterial lumen characterize subclinical atherosclerosis. To better understand the incidence and epidemiological features of ALL in Shanghai, we conducted a retrospective survey based on the database from the Shanghai Center for Disease Control and Prevention (CDC) and the medical records in all large-scale hospitals in Shanghai, especially those 30 major hospitals with hematology department. Of these 25 bones, 5 had been labeled in vivo with fluorochrome markers. A different definition of schizophrenia probably accounts for the greater part of the different results in this and previous studies. However, further studies on the isolation and characterization of active constituents of PECQ, which can cross the placental barrier and are responsible for the bone anabolic activity are warranted.

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