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Tolbin (Metronidazole)

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Tolbin eliminates bacteria and other microorganisms that cause infections of the reproductive system, gastrointestinal tract, skin, vagina, and other areas of the body. Antibiotics will not work for colds, flu, or other viral infections. This medication is sometimes prescribed for other uses; ask your doctor or pharmacist for more information.

Other names for this medication:
Acuzole, Anaeromet, Arilin, Birodogyl, Buccoval, Collazole, Efloran, Flagemed, Flagolin, Ginerella, Lindoplus, Medazol, Metco, Metrazol, Metrogyl, Metronidazole, Metrosil, Metrozine, Nidazole, Noritate, Orogyl, Orvagil, Protogyl, Repligen, Rosasol, Rosazol, Unigyl, Varizil

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Also known as: Metronidazole


Generic Tolbin is created by pharmacy specialists to struggle with dangerous infections spread by bacteria (it can be protozoa or anaerobic bacteria). Target of Generic Tolbin is to control, ward off and terminate bacteria. Generic Tolbin acts as an anti-infection remedy. Generic Tolbin operates by killing bacteria which spreads by infection. Tolbin is also known as Metronidazole. Generic Tolbin and other antibiotics don"t treat viral infections (flu, cold and other). Generic Tolbin also does not help with vaginal yeast infection. Generic name of Generic Tolbin is Metronidazole. Brand names of Generic Tolbin are Protostat, Tolbin, Tolbin ER, Tolbin 375.


In the Female. One-day treatment – two grams of Tolbin, given either as a single dose or in two divided doses of one gram each, given in the same day. Seven-day course of treatment – 250 mg three times daily for seven consecutive days. There is some indication from controlled comparative studies that cure rates as determined by vaginal smears and signs and symptoms, may be higher after a seven-day course of treatment than after a one-day treatment regimen.

The dosage regimen should be individualized. Single-dose treatment can assure compliance, especially if administered under supervision, in those patients who cannot be relied on to continue the seven-day regimen. A seven-day course of treatment may minimize reinfection by protecting the patient long enough for the sexual contacts to obtain appropriate treatment. Further, some patients may tolerate one treatment regimen better than the other.

Pregnant patients should not be treated during the first trimester In pregnant patients for whom alternative treatment has been inadequate, the one-day course of therapy should not be used, as it results in higher serum levels which can reach the fetal circulation.

When repeat courses of the drug are required, it is recommended that an interval of four to six weeks elapse between courses and that the presence of the trichomonad be reconfirmed by appropriate laboratory measures. Total and differential leukocyte counts should be made before and after re-treatment.


Single oral doses of Tolbin, up to 15 g, have been reported in suicide attempts and accidental overdoses. Symptoms reported include nausea, vomiting, and ataxia. Oral Tolbin has been studied as a radiation sensitizer in the treatment of malignant tumors. Neurotoxic effects, including seizures and peripheral neuropathy, have been reported after 5 to 7 days of doses of 6 to 10.4 g every other day.

There is no specific antidote for Tolbin overdose; therefore, management of the patient should consist of symptomatic and supportive therapy.


Store at room temperature below 25 degrees C (77 degrees F) away from moisture, light and heat. Keep container tightly closed. Throw away any unused medicine after the expiration date. Keep out of the reach of children.

Side effects

The most common side effects associated with Tolbin are:

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Side effect occurrence does not only depend on medication you are taking, but also on your overall health and other factors.


As a rule, the usual duration of therapy with i.v Metronidazole or other imidazole derivatives is usually less than 10 days. This period may only be exceeded in individual cases after a very strict benefit-risk assessment. Only in the rarest possible case should the treatment be repeated. Limiting the duration of treatment is necessary because damage to human germ cells cannot be excluded.

Intensive or prolonged Metronidazole therapy should be conducted only under conditions of close surveillance for clinical and biological effects and under specialist direction. If prolonged therapy is required, the physician should bear in mind the possibility of peripheral neuropathy or leucopenia. Both effects are usually reversible.

In case of prolonged treatment, occurrence of undesirable effects such as paraesthesia, ataxia, dizziness and convulsive crises should be checked. High dose regimes have been associated with transient epileptiform seizures.

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