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Trichozole (Metronidazole)
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Trichozole

Trichozole is an antibiotic and antiprotozoal medication. It is used either alone or with other antibiotics to treat pelvic inflammatory disease, endocarditis, and bacterial vaginosis. It is effective for dracunculiasis, giardiasis, trichomoniasis, and amebiasis.

Other names for this medication:
Aldezol, Amodis, Amrizole, Arilin, Colpofilin, Deprocid, Dequazol, Dirozyl, Efloran, Entizol, Etron, Farnat, Flagicure, Flazol, Flazole, Florazole, Geloderm, Kilpro, Metrajil, Metrocreme, Metrofusin, Metrogel, Metrogyl, Metrol, Metrolag, Metrolyl, Metronidazole, Metronidazols, Metronidazolum, Metronour, Metrozin, Micogyl, Minegyl, Missilor, Nidazol, Nidazole, Novazole, Orvagil, Perilox, Protogyl, Riazole, Robaz, Rosasol, Rosiced, Rovamet, Rozagel, Rozamet, Vertisal

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Also known as: Metronidazole

Description

Trichozole (generic name: Metronidazole) is an antibiotic that belongs to a group of medicines called nitroimidazoles.

Trichozole is used for the treatment of susceptible anaerobic bacterial and protozoal infections in the following conditions: amebiasis, symptomatic and asymptomatic trichomoniasis; skin and skin structure infections; CNS infections; intra-abdominal infections (as part of combination regimen); systemic anaerobic infections; treatment of antibiotic-associated pseudomembranous colitis (AAPC); bacterial vaginosis; as part of a multidrug regimen for H. pylori eradication to reduce the risk of duodenal ulcer recurrence.

Dosage

In the Female. One-day treatment – two grams of Trichozole, given either as a single dose or in two divided doses of one gram each, given in the same day. Seven-day course of treatment – 250 mg three times daily for seven consecutive days. There is some indication from controlled comparative studies that cure rates as determined by vaginal smears and signs and symptoms, may be higher after a seven-day course of treatment than after a one-day treatment regimen.

The dosage regimen should be individualized. Single-dose treatment can assure compliance, especially if administered under supervision, in those patients who cannot be relied on to continue the seven-day regimen. A seven-day course of treatment may minimize reinfection by protecting the patient long enough for the sexual contacts to obtain appropriate treatment. Further, some patients may tolerate one treatment regimen better than the other.

Pregnant patients should not be treated during the first trimester In pregnant patients for whom alternative treatment has been inadequate, the one-day course of therapy should not be used, as it results in higher serum levels which can reach the fetal circulation.

When repeat courses of the drug are required, it is recommended that an interval of four to six weeks elapse between courses and that the presence of the trichomonad be reconfirmed by appropriate laboratory measures. Total and differential leukocyte counts should be made before and after re-treatment.

Overdose

In cases of overdose in adults, the clinical symptoms are usually limited to nausea, vomiting, ataxia and slight disorientation. In a preterm newborn, no clinical or biological sign of toxicity developed.

There is no specific treatment for Trichozole overdose, Trichozole infusion should be discontinued. Patients should be treated symptomatically.

Storage

Keep this medication in the container it came in, tightly closed, and out of reach of children. Store it at room temperature and away from excess heat and moisture (not in the bathroom). Throw away any medication that is outdated or no longer needed. Talk to your pharmacist about the proper disposal of your medication.

Side effects

The most common side effects associated with Trichozole are:

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Side effect occurrence does not only depend on medication you are taking, but also on your overall health and other factors.

Contraindications

Psychotic Reaction with Disulfiram. Use of oral metronidazole is associated with psychotic reactions in alcoholic patients who were using disulfiram concurrently. Do not administer metronidazole to patients who have taken disulfiram within the last two weeks.

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A number of new studies that illustrate this approach with patients with schizophrenia spectrum disorders who have not responded to previous treatment are reviewed. Understanding the mechanisms regulating normal and pathological angiogenesis is of great scientific and clinical interest. Disulphide bonds and the 118,000 Mr glycoprotein of human intestinal mucin. Importantly, we show that IL-21-positive cells are increased in the bronchial mucosa of asthmatics compared with non-asthmatics. Elastic motion is a nonrigid motion constrained only by some degree of smoothness and continuity. Creation of a transverse colon--gastric composite reservoir: a new technique.

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